Holtappels Dominique, Fortuna Kiandro, Lavigne Rob, Wagemans Jeroen
Laboratory of Gene Technology, Department of Biosystems, KU Leuven, Belgium.
Laboratory of Gene Technology, Department of Biosystems, KU Leuven, Belgium.
Curr Opin Biotechnol. 2021 Apr;68:60-71. doi: 10.1016/j.copbio.2020.08.016. Epub 2020 Nov 8.
Bacterial phytopathogens significantly reduce crop yields and hence, pose a threat to the food supply of our increasing world population. In this context, bacteriophages are investigated as potential sustainable biocontrol agents. Here, recent advances in phage biocontrol are reviewed and considered within the framework of integrated plant protection strategies. This shows that understanding the pathogen's biology is crucial to develop a targeted strategy, tailored to individual pathosystems and driven by biotechnological insights. Moreover, the potential synergy of phages in contemporary farming practices based on the Internet of Things is proposed, potentially enabling a timely and cost-efficient treatment of plants at an early stage of the disease. Finally, these prospects are placed in the regulatory context of virus-oriented integrated pest control.
细菌性植物病原体显著降低作物产量，因此，对不断增长的世界人口的粮食供应构成威胁。在这种背景下，噬菌体作为潜在的可持续生物防治剂受到研究。在此，对噬菌体生物防治的最新进展进行综述，并在综合植物保护策略的框架内加以考量。这表明，了解病原体的生物学特性对于制定针对个体病理系统并由生物技术见解驱动的靶向策略至关重要。此外，还提出了基于物联网的当代农业实践中噬菌体的潜在协同作用，这有可能在疾病早期对植物进行及时且经济高效的处理。最后，将这些前景置于以病毒为导向的综合害虫防治的监管背景中。
