Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
World J Biol Psychiatry. 2021 Sep;22(7):552-556. doi: 10.1080/15622975.2020.1849796. Epub 2020 Dec 1.
Negative symptoms of schizophrenia can be related to metabolic abnormalities. The study aimed to assess negative symptoms using the Positive and Negative Syndrome Scale (PANSS) and the Brief Negative Symptoms Scale (BNSS), and their relationship with body mass index (BMI) and lipid indices, in male and female schizophrenic patients.
Fifty chronic schizophrenia patients (29 males, 21 females) were included. They have mild to moderate severity of the illness (total PANSS score <80), and received unchanged pharmacological treatment in the last three weeks. Psychopathology symptoms were assessed using the PANSS and BNSS. The measurements of BMI and serum lipids were done in all patients.
In female patients, a significant positive correlation between the intensity of negative symptoms measured by the PANSS and BNSS scales and the concentration of high-density lipoprotein (HDL) cholesterol, and a trend for negative correlation with BMI was observed. Such correlations were not found in male patients.
Assessing the negative symptoms of schizophrenia, and investigating the relationship of these symptoms with metabolic indices, we showed distinctive features in male and female schizophrenia patients. The positive correlation between negative symptoms and HDL cholesterol in female patients needs to be confirmed in further studies.
精神分裂症的阴性症状可能与代谢异常有关。本研究旨在评估男性和女性精神分裂症患者的阴性症状，使用阳性和阴性症状量表（PANSS）和简要阴性症状量表（BNSS），并评估它们与体重指数（BMI）和血脂指数的关系。
共纳入 50 例慢性精神分裂症患者（29 名男性，21 名女性）。这些患者的疾病严重程度为轻至中度（总 PANSS 评分<80），且在过去 3 周内未改变药物治疗。使用 PANSS 和 BNSS 评估精神病理学症状。所有患者均进行 BMI 和血清脂质测量。
在女性患者中，PANSS 和 BNSS 量表测量的阴性症状严重程度与高密度脂蛋白（HDL）胆固醇浓度呈正相关，与 BMI 呈负相关趋势。在男性患者中未发现这种相关性。
评估精神分裂症的阴性症状，并研究这些症状与代谢指标的关系，我们发现男性和女性精神分裂症患者具有不同的特征。需要进一步研究以确认女性患者阴性症状与 HDL 胆固醇之间的正相关关系。
