Shuyu Han, MSN, RN, is a Doctoral Candidate, School of Nursing, Fudan University, Shanghai, China. Yan Hu, PhD, RN, FAAN, is a Professor and Dean, School of Nursing, Fudan University, Shanghai, China, and is the Director of Fudan University Centre for Evidence-based Nursing: A Joanna Briggs Institute Centre of Excellence, Shanghai, China. Michael V. Relf, PhD, RN, AACRN, ANEF, FAAN, is the Editor-in-Chief of JANAC and Associate Dean for Global and Community Health Affairs, Duke University, School of Nursing, Durham, North Carolina, USA. Marta I. Mulawa, PhD, MHS, is the Assistant Professor of Nursing and Global Health, Duke University, School of Nursing, Durham, North Carolina, USA. Hongzhou Lu, PhD, is the President, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. Lin Zhang, BSN, RN, is a Vice Director of Nursing, Shanghai Public Health Clinical Nursing, Fudan University, Shanghai, China. Zheng Zhu, PhD, RN, is a Faculty Member, School of Nursing, Fudan University, Shanghai, China, and is a Core Researcher of Fudan University Centre for Evidence-based Nursing: A Joanna Briggs Institute Centre of Excellence, Shanghai, China. Jianfeng Luo, PhD, is a Professor, School of Public Health, Fudan University, Shanghai, China. Yaolin Pei, PhD, is a Post-doctoral Fellow, Rory Meyers College of Nursing, New York University, New York, New York, USA. Bei Wu, PhD, is the Dean's Professor in Global Health, the Director for Global Health and Aging Research, and the Director for Research, Hartford Institute for Geriatric Nursing, Rory Meyers College of Nursing, New York University, New York, New York, USA.
J Assoc Nurses AIDS Care. 2021;32(1):79-93. doi: 10.1097/JNC.0000000000000213.
Depression and anxiety, which may influence antiretroviral therapy (ART) medication adherence, are prevalent among persons living with HIV (PLWH) in China. This parallel two-arm clinical controlled trial aimed to examine the effects of a nurse-delivered cognitive behavioral intervention (CBI) on depression, anxiety, and ART medication adherence in Chinese PLWH. Using in-person and online recruitment, 140 PLWH ages 18 years and older who were undergoing ART and had a Patient Health Questionnaire-4 score of ≥2 were assigned to the 10-week-long CBI group or the routine follow-up group according to their preference. Outcomes were measured at baseline, postintervention, and 6-month follow-up. Results showed significant intervention effects on depression maintained until the 6-month follow-up. Although anxiety and ART medication adherence did not show robust effects between conditions, amelioration trends for these outcomes were also found. Our study demonstrated that the nurse-delivered CBI could help Chinese PLWH ameliorate depression.
抑郁和焦虑，可能会影响抗逆转录病毒治疗（ART）药物的依从性，在我国 HIV 感染者（PLWH）中很常见。本项平行、双臂的临床对照试验旨在研究护士提供的认知行为干预（CBI）对中国 PLWH 的抑郁、焦虑和 ART 药物依从性的影响。通过面访和在线招募，140 名年龄在 18 岁及以上、正在接受 ART 治疗且患者健康问卷-4 评分≥2 的 PLWH 根据自身偏好被分配到为期 10 周的 CBI 组或常规随访组。在基线、干预后和 6 个月随访时评估结局。结果显示，干预对抑郁的影响一直持续到 6 个月随访。虽然焦虑和 ART 药物依从性在组间没有显示出显著的效果，但也发现了这些结局的改善趋势。我们的研究表明，护士提供的 CBI 可以帮助中国 PLWH 改善抑郁。
