Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Sci Rep. 2020 Nov 11;10(1):19563. doi: 10.1038/s41598-020-76531-2.
This study aimed to determine the risk factors related to regression and progression of metabolic syndrome, in a 4-year cohort study. A total of 540 individuals (≥ 18 years old) participated in both phase of the study. Participants were categorized into 3 categories of regressed, progressed and unchanged metabolic syndrome (MetS). Demographic, anthropometric and biochemical parameters were assessed for each individual in both phase. Variables differences (delta: Δ) between the two phase of study were calculated. Unchanged group was considered as baseline category. Based on IDF, MetS had been regressed and progressed in 42 participants (7.7%) and 112 (20.7%) participants respectively, in the second phase. More than 47% of people, whose MetS regressed, experienced also NAFLD regression. Results of multiple variable analysis revealed that increased age, positive Δ-TG, and Δ-FBS, significantly increased the odds of MetS progression based on IDF and ATP III definitions, while negative Δ-HDL and Δ-neutrophil to lymph ration increased the odds of progression. On the other hand, negative Δ-TG and positive Δ-HDL significantly increased the odds of Mets regression based of both IDF and ATP III. Management of hypertriglyceridemia, hyperglycemia, and HDL is a critical, non-invasive and accessible approach to change the trend of MetS.
本研究旨在确定与代谢综合征消退和进展相关的风险因素，采用了一项为期 4 年的队列研究。共有 540 名（≥18 岁）个体参与了研究的两个阶段。参与者被分为代谢综合征（MetS）消退、进展和不变的 3 个类别。在两个阶段都评估了每个个体的人口统计学、人体测量学和生化参数。计算了两个阶段之间的变量差异（差值：Δ）。不变组被视为基线类别。根据 IDF，在第二阶段，42 名（7.7%）和 112 名（20.7%）参与者的 MetS 分别消退和进展。超过 47%的 MetS 消退者也经历了非酒精性脂肪性肝病（NAFLD）的消退。多变量分析的结果表明，基于 IDF 和 ATP III 定义，年龄增长、正Δ-TG 和Δ-FBS 显著增加了 MetS 进展的几率，而负Δ-HDL 和Δ中性粒细胞与淋巴细胞比值则增加了进展的几率。另一方面，负Δ-TG 和正Δ-HDL 显著增加了 IDF 和 ATP III 两种情况下 MetS 消退的几率。管理高甘油三酯血症、高血糖和高密度脂蛋白（HDL）是改变 MetS 趋势的关键、非侵入性和可及的方法。
