Weill J C, Reynaud C A
Institut Jacques Monod, CNRS, Université Paris, France.
Science. 1987 Nov 20;238(4830):1094-8. doi: 10.1126/science.3317827.
A very unusual molecular mechanism is involved in generating the preimmune repertoire in the chicken bursa of Fabricius. A unique rearranged V gene is diversified through a program of segmental gene conversion with a pool of noncoding pseudogenes being used as donors. A specifically committed progenitor that originates in the embryonic bursa is responsible for long-term maintenance of the B cell population. Both these properties and the characteristics of the peripheral B cell compartment are discussed in terms of the evolution of the T and B immune systems.
一种非常独特的分子机制参与了鸡法氏囊中免疫前库的产生。一个独特的重排V基因通过与一组用作供体的非编码假基因进行节段性基因转换程序而多样化。起源于胚胎法氏囊的一个特定定向祖细胞负责B细胞群体的长期维持。本文从T和B免疫系统的进化角度讨论了这些特性以及外周B细胞区室的特征。
