Dimitrova Iva N
Cardiology, St. Ekaterina University Hospital, Medical University of Sofia, Sofia, BGR.
Cureus. 2020 Oct 10;12(10):e10887. doi: 10.7759/cureus.10887.
5-Fluorouracil (5-FU), a pyrimidine analogue, is widely used in different chemotherapy regimens with established indications for the treatment of gastrointestinal, breast, head, and neck tumors. Various prospective studies including randomized controlled trials and retrospective reviews have shown a wide range of reported incidence of cardiotoxicity related to 5-FU use. This incidence is dependent on drug regimen, doses, concomitant therapy, patients' clinical characteristics, and risk factors. Herein, we present a clinical case of coronary vasospasm mimicking ST-elevation myocardial infarction during a 5-FU infusion for salivary gland cancer. Cardiologists and oncologists must keep in mind the potential life-threatening side effects of 5-FU on the heart and they must be familiar with the risk factors for their occurrence and their management strategies.
5-氟尿嘧啶（5-FU）是一种嘧啶类似物，广泛应用于不同的化疗方案中，用于治疗胃肠道、乳腺、头颈部肿瘤等有明确适应证的疾病。包括随机对照试验和回顾性综述在内的各种前瞻性研究表明，与使用5-FU相关的心脏毒性发生率报道范围很广。这一发生率取决于药物方案、剂量、联合治疗、患者的临床特征和危险因素。在此，我们报告一例在为唾液腺癌输注5-FU期间发生类似ST段抬高型心肌梗死的冠状动脉痉挛临床病例。心脏病学家和肿瘤学家必须牢记5-FU对心脏潜在的危及生命的副作用，并且必须熟悉其发生的危险因素及其管理策略。
