Horton Mark V, Nett Jeniel E
University of Wisconsin-Madison, Departments of Medicine and Medical Microbiology & Immunology, Wisconsin, United States of America.
Curr Clin Microbiol Rep. 2020 Sep;7(3):51-56. doi: 10.1007/s40588-020-00143-7. Epub 2020 Jul 17.
Emergent fungal pathogen is spreading in hospitals throughout the world and mortality rates for patients with invasive disease approach 60%. This species exhibits a heightened capacity to colonize skin, persist on hospital surfaces, rapidly disseminate in healthcare settings, and resist antifungal therapy.
Current investigations show that produces biofilms, surface-adherent communities that resist antifungals and withstand desiccation. These biofilms form when is growing on skin or in conditions expected in the hospital environment and on implanted medical devices.
Here we will highlight the topic of biofilm formation by . We illustrate how this process influences resistance to antimicrobials and promotes nosocomial transmission.
新兴真菌病原体正在全球医院中传播,侵袭性疾病患者的死亡率接近60%。该菌种在皮肤定殖、在医院表面存活、在医疗机构中快速传播以及抵抗抗真菌治疗方面能力增强。
当前研究表明,该菌可形成生物膜,即一种抵抗抗真菌药物并耐受干燥的表面附着群落。当该菌在皮肤或医院环境预期条件下以及植入式医疗设备上生长时,就会形成这些生物膜。
在此,我们将重点介绍该菌形成生物膜的主题。我们阐述了这一过程如何影响对抗菌药物的耐药性并促进医院内传播。