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Multikinase inhibitors to treat hepatocellular carcinoma failures to sorafenib-time has come for a better approach.

作者信息

Alqahtani Saleh A, Colombo Massimo

机构信息

Liver Transplant Unit, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.

Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD, USA.

出版信息

Ann Transl Med. 2020 Oct;8(19):1255. doi: 10.21037/atm-2020-79.

DOI:10.21037/atm-2020-79
PMID:33178787
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7607112/
Abstract
摘要

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Ann Transl Med. 2020 Oct;8(19):1255. doi: 10.21037/atm-2020-79.
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Systems analysis identifies endothelin 1 axis blockade for enhancing the anti-tumor effect of multikinase inhibitor.系统分析确定内皮素 1 轴阻断剂可增强多激酶抑制剂的抗肿瘤作用。
Cancer Gene Ther. 2022 Jun;29(6):845-858. doi: 10.1038/s41417-021-00373-x. Epub 2021 Aug 6.

本文引用的文献

1
Insights into the success and failure of systemic therapy for hepatocellular carcinoma.对肝细胞癌系统治疗成败的深入了解。
Nat Rev Gastroenterol Hepatol. 2019 Oct;16(10):617-630. doi: 10.1038/s41575-019-0179-x. Epub 2019 Aug 1.
2
Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial.瑞戈非尼治疗后索拉非尼治疗失败的晚期肝细胞癌患者的 Ramucirumab(REACH-2):一项随机、双盲、安慰剂对照、3 期临床试验。
Lancet Oncol. 2019 Feb;20(2):282-296. doi: 10.1016/S1470-2045(18)30937-9. Epub 2019 Jan 18.
3
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018:GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
4
Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma.卡博替尼治疗晚期和进展性肝细胞癌患者。
N Engl J Med. 2018 Jul 5;379(1):54-63. doi: 10.1056/NEJMoa1717002.
5
Regional Differences in Efficacy, Safety, and Biomarkers for Second-Line Axitinib in Patients with Advanced Hepatocellular Carcinoma: From a Randomized Phase II Study.晚期肝细胞癌患者二线使用阿昔替尼的疗效、安全性及生物标志物的区域差异:来自一项随机II期研究
Liver Cancer. 2018 May;7(2):148-164. doi: 10.1159/000484620. Epub 2017 Dec 8.
6
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma.欧洲肝脏研究学会临床实践指南:肝细胞癌的管理
J Hepatol. 2018 Jul;69(1):182-236. doi: 10.1016/j.jhep.2018.03.019. Epub 2018 Apr 5.
7
Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial.乐伐替尼与索拉非尼用于不可切除肝细胞癌患者一线治疗的比较:一项随机、III 期非劣效性试验。
Lancet. 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1.
8
AASLD guidelines for the treatment of hepatocellular carcinoma.美国肝病研究学会肝细胞癌治疗指南。
Hepatology. 2018 Jan;67(1):358-380. doi: 10.1002/hep.29086.
9
Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial.regorafenib 用于索拉非尼治疗后进展的肝细胞癌患者(RESORCE):一项随机、双盲、安慰剂对照、3 期试验。
Lancet. 2017 Jan 7;389(10064):56-66. doi: 10.1016/S0140-6736(16)32453-9. Epub 2016 Dec 6.
10
Ramucirumab as second-line treatment in patients with advanced hepatocellular carcinoma: Japanese subgroup analysis of the REACH trial.雷莫西尤单抗作为晚期肝细胞癌患者的二线治疗:REACH试验的日本亚组分析
J Gastroenterol. 2017 Apr;52(4):494-503. doi: 10.1007/s00535-016-1247-4. Epub 2016 Aug 22.