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肿瘤微环境在卡介苗治疗疗效中的作用。

Role of tumor microenvironment in the efficacy of BCG therapy.

作者信息

Ibrahim Omar M, Pandey Ravindra K, Chatta Gurkamal, Kalinski Pawel

机构信息

Department of Medicine, Division of Translational Research, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.

Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.

出版信息

Trends Res. 2020 Oct;3(4). doi: 10.15761/tr.1000170. Epub 2020 Aug 17.

DOI:10.15761/tr.1000170
PMID:33178990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7654968/
Abstract

Despite its significant overall efficacy, BCG fails to benefit a substantial proportion of bladder cancer (BlCa) patients. Here, we review recent data highlighting the role of tumor microenvironment (TME) in limiting antitumoral activity of BCG treatment and emerging opportunities to target TME to enhance the overall outcomes in BCG-treated BlCa patients.

摘要

尽管卡介苗（BCG）具有显著的总体疗效，但仍有相当一部分膀胱癌（BlCa）患者无法从中获益。在此，我们回顾近期数据，这些数据突出了肿瘤微环境（TME）在限制BCG治疗的抗肿瘤活性方面所起的作用，以及针对TME以改善接受BCG治疗的BlCa患者总体预后的新机遇。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b40d/7654968/4364982f7b10/nihms-1635958-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b40d/7654968/4364982f7b10/nihms-1635958-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b40d/7654968/4364982f7b10/nihms-1635958-f0001.jpg

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2
Adaptive Immune Resistance to Intravesical BCG in Non-Muscle Invasive Bladder Cancer: Implications for Prospective BCG-Unresponsive Trials.非肌肉浸润性膀胱癌膀胱内卡介苗免疫抵抗的适应性：对前瞻性卡介苗无反应试验的影响。
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Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy.
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