Mahony C
Division of Cardiology, University of Kentucky, Lexington 40536.
Thromb Res. 1987 Sep 15;47(6):665-72. doi: 10.1016/0049-3848(87)90105-8.
The echogenicity of platelet aggregates in platelet-rich plasma and whole blood was evaluated in stirring and flowing in vitro models. Real-time two dimensional ultrasonic images were obtained with transducers operating at 3.0, 5.0, 10 and 12 mHz. Platelet-rich plasma was not echogenic. The addition of adenosine diphosphate (ADP) resulted in the formation of multiple, discrete echoes that increased in size and intensity. This echogenicity was time and dose-dependent and could be quantitated by videodensitometry. Whole blood was echogenic, but the addition of ADP resulted in a time and dose-dependent increase in the size and echogenicity of the reflections. The overall echogenicity of whole blood declined with the development of platelet aggregates. There is inter- and intra-aggregate variability in the echogenicity of aggregates. Aggregates were best seen with transducers operating at the higher frequencies. These results imply that the detection of in vivo platelet aggregates may be feasible with ultrasonic imaging.
在搅拌和流动的体外模型中评估富血小板血浆和全血中血小板聚集体的回声性。使用工作频率为3.0、5.0、10和12兆赫兹的换能器获取实时二维超声图像。富血小板血浆无回声。添加二磷酸腺苷（ADP）导致形成多个离散回声，其大小和强度增加。这种回声性具有时间和剂量依赖性，可通过视频密度测定法进行定量。全血有回声，但添加ADP导致反射的大小和回声性出现时间和剂量依赖性增加。随着血小板聚集体的形成，全血的总体回声性下降。聚集体的回声性在聚集体之间和内部存在差异。使用较高频率工作的换能器能最佳观察到聚集体。这些结果表明，通过超声成像检测体内血小板聚集体可能是可行的。
