Department of Clinical Pathology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt.
Department of Dermatology & Venereology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt.
Egypt J Immunol. 2020 Jan;27(1):157-168.
Psoriasis vulgaris (PsV) is common, incurable, pro-inflammatory systemic disease with waving course that impacts the life quality. This justifies the need for discovering simple biomarkers with key roles in monitoring systemic inflammation and assessing the disease severity. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) have been suggested as markers of inflammation. We aimed to investigate the role of NLR, PLR and MPV as biomarkers for PsV disease and to examine their possible association with disease severity assessed by Psoriasis Area and Severity Index (PASI score) in Egyptian psoriatic patients. This case control study included 36 PsV patients and 36 healthy controls. Hematological parameters were assessed by automated KX21N cell counters. Significant increase was detected in NLR (P < 0.001) and PLR (P < 0.001) in PsV patients when compared to controls. PASI score positively correlated with PLR (r=0.405; P=0.014) and negatively correlated with MPV (r= -0.471; P=0.004). NLR positively correlated with disease duration/ years (r=0.414; P=0.012). ROC curves data output showed that NLR at cut off of 1.66 yielded a specificity of (94.4%) and sensitivity of (61.1%) (P < 0,001) to differentiate PsV patients from healthy individuals and, PLR at cut-off of 110.6 yielded a higher sensitivity of (77.81%) with specificity of (86.1%) (P < 0.001). We concluded that NLR and PLR can serve as biomarkers for systemic inflammation in PsV disease. Increased NLR is more influenced by disease duration than disease severity. PLR and MPV can be applied to monitor psoriasis vulgaris severity and follow up of patients.
寻常型银屑病（PsV）是一种常见的、无法治愈的、炎症性系统性疾病，其病程呈波动状，会影响生活质量。这就需要寻找一些简单的生物标志物，这些标志物在监测全身炎症和评估疾病严重程度方面发挥着关键作用。中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和平均血小板体积（MPV）已被提议作为炎症标志物。我们旨在研究 NLR、PLR 和 MPV 作为 PsV 疾病生物标志物的作用，并检查它们与埃及银屑病患者的银屑病面积和严重程度指数（PASI 评分）评估的疾病严重程度之间的可能相关性。这项病例对照研究纳入了 36 例 PsV 患者和 36 例健康对照者。通过自动 KX21N 细胞计数器评估血液学参数。与对照组相比，PsV 患者的 NLR（P < 0.001）和 PLR（P < 0.001）显著升高。PASI 评分与 PLR 呈正相关（r=0.405；P=0.014），与 MPV 呈负相关（r=-0.471；P=0.004）。NLR 与疾病持续时间/年呈正相关（r=0.414；P=0.012）。ROC 曲线数据输出显示，NLR 截断值为 1.66 时，对区分 PsV 患者和健康个体的特异性为（94.4%），敏感性为（61.1%）（P < 0.001），PLR 截断值为 110.6 时，敏感性为（77.81%），特异性为（86.1%）（P < 0.001）。我们得出结论，NLR 和 PLR 可作为 PsV 疾病全身炎症的生物标志物。NLR 受疾病持续时间的影响比疾病严重程度更大。PLR 和 MPV 可用于监测寻常型银屑病的严重程度并对患者进行随访。
