MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, Oxfordshire, UK.
University College London Hospitals NHS Foundation Trust, London, UK.
Arch Dermatol Res. 2024 Feb 8;316(3):85. doi: 10.1007/s00403-024-02823-6.
Psoriasis is a chronic, inflammatory skin disorder characterized by well-demarcated erythematous lesions with surface scaling. The disease is underpinned by a dysregulated immune response with a shift in the balance of neutrophils, lymphocytes and platelets. We sought to evaluate the novel systemic inflammatory markers, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), as psoriatic indicators. Pubmed, Web of Science and Scopus were systematically searched for relevant studies. Twenty-four studies consisting of a total of 2,275 psoriatic patients (1,301 males and 974 females) and 2,334 healthy controls (1,401 males and 933 females) were identified for inclusion in the quantitative analysis. The NLR and PLR were found to be significantly increased in psoriatic patients [standardized mean difference (SMD) = 0.68, 95% CI 0.56-0.80, p < 0.01, and SMD = 0.37, 95% CI 0.14-0.60, p < 0.01, respectively]. However, no association between the NLR and PLR with psoriasis severity was detected (p = 0.93, and p = 0.83, respectively). In conclusion, the NLR and PLR are simple and cost-effective markers of psoriatic presence, but their value as severity markers requires further study.
银屑病是一种慢性炎症性皮肤病，其特征为边界清楚的红斑，表面有鳞屑。该病是由免疫失调引起的，中性粒细胞、淋巴细胞和血小板之间的平衡发生了转变。我们试图评估新型全身性炎症标志物中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）作为银屑病的指标。我们系统地检索了 Pubmed、Web of Science 和 Scopus 中的相关研究。共有 24 项研究（共纳入 2275 例银屑病患者，其中 1301 例男性，974 例女性，和 2334 例健康对照，其中 1401 例男性，933 例女性）被纳入定量分析。结果发现银屑病患者的 NLR 和 PLR 显著升高[标准化均数差（SMD）=0.68，95%置信区间（CI）0.56-0.80，p<0.01，和 SMD=0.37，95%CI 0.14-0.60，p<0.01]。然而，NLR 和 PLR 与银屑病严重程度之间没有相关性（p=0.93，和 p=0.83，分别）。总之，NLR 和 PLR 是银屑病存在的简单且经济有效的标志物，但它们作为严重程度标志物的价值还需要进一步研究。
