MR 淋巴造影术联合超顺磁性氧化铁对 N0 期口腔癌前哨淋巴结的定位：一项初步研究。
MR lymphography with superparamagnetic iron oxide for sentinel lymph node mapping of N0 early oral cancer: A pilot study.
机构信息
Department of Oral and Maxillofacial Surgery/Orthodontics, Yokohama City University hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan.
Department of Radiology, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan.
出版信息
Dentomaxillofac Radiol. 2021 May 1;50(4):20200333. doi: 10.1259/dmfr.20200333. Epub 2020 Nov 17.
OBJECTIVES
The purpose of this pilot study was to evaluate the usefulness of magnetic resonance lymphography (MRL) with superparamagnetic iron oxide (SPIO) in sentinel lymph node (SLN) mapping of clinically N0 early oral cancer, and to conduct a comparative study of this MRL with CT lymphography (CTL).
METHODS
CTL and MRL were performed for SLN mapping before surgery for 20 patients with clinically N0 early oral cancer. The detection rate, number, and location of SLNs in CTL and MRL were evaluated. Furthermore, optimal scanning/imaging timing in MRL was examined.
RESULTS
SLNs were detected by CTL in 18 (90%) patients, and the total and mean number of SLN were 35 and 1.8, respectively. All SLNs could be detected 2 min and 3.5-5 min after contrast medium injection. In all patients, SLNs were detected by MRL at 10 min after SPIO injection, and the total and mean number of SLN was 53 and 2.7, respectively. MRL at 30 min after the injection showed additional 18 secondary lymph nodes.
CONCLUSION
MRL with SPIO is safe and useful imaging for the detection of SLNs in clinically N0 early oral cancer, and the optimal imaging timing is 10 min after SPIO injection.
目的
本初步研究旨在评估超顺磁氧化铁（SPIO）磁共振淋巴造影（MRL）在临床 N0 期早期口腔癌前哨淋巴结（SLN）定位中的作用，并对 MRL 与 CT 淋巴造影（CTL）进行对比研究。
方法
对 20 例临床 N0 期早期口腔癌患者在术前分别行 CTL 和 MRL 行 SLN 定位。评估 CTL 和 MRL 对 SLN 的检出率、数量和位置。此外，还对 MRL 的最佳扫描/成像时间进行了研究。
结果
CTL 可检出 18 例（90%）患者的 SLN，SLN 的总数和平均数量分别为 35 个和 1.8 个。所有 SLN 在造影剂注射后 2 分钟和 3.5-5 分钟均可检出。所有患者在 SPIO 注射后 10 分钟通过 MRL 可检出 SLN，SLN 的总数和平均数量分别为 53 个和 2.7 个。SPIO 注射后 30 分钟的 MRL 显示出另外 18 个二级淋巴结。
结论
SPIO 磁共振淋巴造影术是一种安全、有效的方法，可用于检测临床 N0 期早期口腔癌患者的 SLN，最佳成像时间为 SPIO 注射后 10 分钟。
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