Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, Shandong Province, People's Republic of China.
Int J Nanomedicine. 2023 Apr 1;18:1741-1763. doi: 10.2147/IJN.S399047. eCollection 2023.
Cancer-related burden of morbidity and mortality is rapidly rising worldwide. Medical imaging plays an important role in every phase of cancer management, including diagnosis, staging, treatment planning and evaluation. Iron oxide nanoparticles (IONPs) could serve as contrast agents or labeling agents to enhance the identification and visualization of pathological tissues as well as target cells. Multimodal or multifunctional imaging can be easily acquired by modifying IONPs with other imaging agents or functional groups, allowing the accessibility of combined imaging techniques and providing more comprehensive information for cancer care. To date, IONPs-enhanced medical imaging has gained intensive application in early diagnosis, monitoring treatment as well as guiding radio-frequency ablation, sentinel lymph node dissection, radiotherapy and hyperthermia therapy. Besides, IONPs mediated imaging is also capable of promoting the development of anti-cancer nanomedicines through identifying patients potentially sensitive to nanotherapeutics. Based on versatile imaging modes and application fields, this review highlights and summarizes recent research advances of IONPs-based medical imaging in cancer management. Besides, currently existing challenges are also discussed to provide perspectives and advices for the future development of IONPs-based imaging in cancer management.
癌症相关的发病率和死亡率负担在全球范围内迅速上升。医学影像学在癌症管理的各个阶段都发挥着重要作用，包括诊断、分期、治疗计划和评估。氧化铁纳米粒子（IONPs）可用作对比剂或标记剂，以增强对病理组织和靶细胞的识别和可视化。通过用其他成像剂或官能团修饰 IONPs，可以很容易地获得多模态或多功能成像，从而实现联合成像技术的应用，并为癌症治疗提供更全面的信息。迄今为止，IONPs 增强的医学成像已在早期诊断、治疗监测以及引导射频消融、前哨淋巴结清扫、放疗和热疗等方面得到了广泛应用。此外，IONPs 介导的成像还能够通过识别对纳米治疗药物敏感的患者，促进抗癌纳米药物的发展。基于多种成像模式和应用领域，本文重点总结了 IONPs 基医学成像在癌症管理中的最新研究进展。此外，还讨论了目前存在的挑战，为 IONPs 基成像在癌症管理中的未来发展提供了观点和建议。
