微生物代谢物强化免疫防火墙。
Microbial Metabolite Fortifies the Immune Firewall.
机构信息
Department of Pathology, University of California San Diego, La Jolla, CA, USA; Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccine, La Jolla, CA, USA; Humans and the Microbiome Program, CIFAR, Toronto, ON, Canada.
出版信息
Cell Host Microbe. 2020 Nov 11;28(5):631-633. doi: 10.1016/j.chom.2020.10.005.
PMID:33181074
Abstract
Clearance of pathogens by Kupffer cells is an important innate immune process in the liver. In this issue of Cell Host & Microbe, McDonald et al. reveal that microbial-derived D-lactate promotes Kupffer-cell-mediated killing of circulating pathogens.
摘要
库普弗细胞对病原体的清除是肝脏中重要的先天免疫过程。在本期《细胞宿主与微生物》中，McDonald 等人揭示了微生物衍生的 D-乳酸促进了库普弗细胞对循环病原体的杀伤作用。
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