Moraes-Pinto Maria Isabel de, Suano-Souza Fabíola, Aranda Carolina S
Universidade Federal de São Paulo, Departamento de Pediatria, Disciplina de Infectologia Pediátrica, São Paulo, SP, Brazil.
Universidade Federal de São Paulo, Departamento de Pediatria, Disciplina de Pediatria Geral e Comunitária, São Paulo, SP, Brazil; Faculdade de Medicina do ABC, Departamento de Pediatria, Disciplina de Clínica Pediátrica, Departamento de Pediatria, Santo André, SP, Brazil.
J Pediatr (Rio J). 2021 Mar-Apr;97 Suppl 1(Suppl 1):S59-S66. doi: 10.1016/j.jped.2020.10.006. Epub 2020 Nov 9.
To describe the ontogeny of the immune system and the adaptive mechanisms of the immune system in the neonatal period, with an emphasis on transplacental antibody transport and breastfeeding.
Non-systematic literature review in the PubMed database.
The last two decades have witnessed a great advance in the knowledge of the immune system since conception. Several investigation tools have provided insight on phenomena that were previously inadequately understood. Still expanding, the functional and molecular investigation of various aspects of the immune system will make it possible to understand how intra-uterus maternal-fetal exchanges, the maternal microbiota interacting with the fetus and newborn, and the acquisition of immunological competence occur in healthy and disease scenarios.
In-depth knowledge of the development of the immune system and of the adaptive mechanisms that allow a safer transition to the extrauterine environment are fundamental components of optimizing maternal and young infant vaccination, as well as the strategies associated with full postnatal development, and the early diagnosis and treatment of innate errors of immunity.
描述新生儿期免疫系统的个体发生及免疫系统的适应性机制，重点关注经胎盘的抗体转运和母乳喂养。
在PubMed数据库中进行的非系统性文献综述。
自受孕以来的二十年见证了免疫系统知识的巨大进步。多种研究工具使人们对以前理解不足的现象有了深入了解。免疫系统各个方面的功能和分子研究仍在不断扩展，这将有助于理解在健康和疾病情况下子宫内母婴交换、母体微生物群与胎儿及新生儿的相互作用以及免疫能力的获得是如何发生的。
深入了解免疫系统的发育以及使向宫外环境更安全过渡成为可能的适应性机制，是优化孕产妇和婴幼儿疫苗接种、与产后全面发育相关的策略以及先天性免疫缺陷的早期诊断和治疗的基本要素。
