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正常妊娠期间的母体免疫适应性。

Maternal Immunological Adaptation During Normal Pregnancy.

机构信息

Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada.

BC Children's Hospital Research Institute, Vancouver, BC, Canada.

出版信息

Front Immunol. 2020 Oct 7;11:575197. doi: 10.3389/fimmu.2020.575197. eCollection 2020.

DOI:10.3389/fimmu.2020.575197
PMID:33133091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7579415/
Abstract

The risk and severity of specific infections are increased during pregnancy due to a combination of physiological and immunological changes. Characterizing the maternal immune system during pregnancy is important to understand how the maternal immune system maintains tolerance towards the allogeneic fetus. This may also inform strategies to prevent maternal fatalities due to infections and optimize maternal vaccination to best protect the mother-fetus dyad and the infant after birth. In this review, we describe what is known about the immunological changes that occur during a normal pregnancy.

摘要

由于生理和免疫变化的综合作用，孕妇在怀孕期间会增加特定感染的风险和严重程度。描述怀孕期间的母体免疫系统对于理解母体免疫系统如何维持对同种异体胎儿的耐受性很重要。这也可能为预防因感染导致的孕产妇死亡并优化母体疫苗接种以最佳保护母婴对和出生后的婴儿提供策略。在这篇综述中，我们描述了正常妊娠期间发生的免疫变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efd9/7579415/d0199b514617/fimmu-11-575197-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efd9/7579415/d0199b514617/fimmu-11-575197-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efd9/7579415/d0199b514617/fimmu-11-575197-g001.jpg

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本文引用的文献

[1]
Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancy.

JCI Insight. 2020-4-9

[2]
Pregnancy-Induced Alterations in NK Cell Phenotype and Function.

Front Immunol. 2019-10-23

[3]
The Effect of Timing of Tetanus-Diphtheria-Acellular Pertussis Vaccine Administration in Pregnancy on the Avidity of Pertussis Antibodies.

Front Immunol. 2019-10-11

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Front Neurol. 2019-10-9

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Normal range of complement components during pregnancy: A prospective study.

Am J Reprod Immunol. 2019-11-12

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[8]
Fc Glycan-Mediated Regulation of Placental Antibody Transfer.

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[9]
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[10]
Distinct phenotype of CD4 T cells driving celiac disease identified in multiple autoimmune conditions.

Nat Med. 2019-3-25

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