Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.
Clin Nucl Med. 2021 Jan;46(1):90-92. doi: 10.1097/RLU.0000000000003375.
A 38-year-old man with newly diagnosed multiple myeloma underwent Ga-pentixafor PET/CT for baseline assessment. Ga-pentixafor PET/CT demonstrated multiple focal bone and bone marrow lesions with intense radioactivity. After 9 cycles of chemotherapy against multiple myeloma, the patient experienced serologically complete remission of myeloma. Consistently, the follow-up Ga-pentixafor PET/CT for PET response showed significantly reduced uptake in the previously chemokine receptor 4-positive bone lesions. However, intense and homogeneous uptake of Ga-pentixafor was noted in the thymus with a smooth contour and slightly increased density, which is possibly caused by thymic hyperplasia after chemotherapy.
一位 38 岁男性，新诊断为多发性骨髓瘤，行 Ga- 培妥昔琼 PET/CT 检查用于基线评估。Ga- 培妥昔琼 PET/CT 显示多处局灶性骨和骨髓病变，伴有强烈放射性。多发性骨髓瘤化疗 9 周期后，患者出现血清学完全缓解。一致的是，随后 Ga- 培妥昔琼 PET/CT 检查提示先前趋化因子受体 4 阳性的骨病变摄取明显减少。然而，胸腺呈均匀一致摄取 Ga- 培妥昔琼，轮廓光滑，密度略增高，可能是化疗后胸腺增生所致。
