Aragona Emanuela, Miserocchi Elisabetta, Arrigo Alessandro, Marchese Alessandro, Bordato Alessandro, Bandello Francesco, Modorati Giulio
Ophthalmology Department, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; and.
Department of Ophthalmology, Ocular Immunology and Uveitis Service, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Retin Cases Brief Rep. 2022 Jan 1;16(1):32-35. doi: 10.1097/ICB.0000000000001087.
To describe a case of immunoglobulin G4-related choroiditis mimicking intraocular lymphoma.
The patient underwent a complete ophthalmological evaluation including multimodal imaging, with structural optical coherence tomography, fluorescein angiography, indocyanine green angiography, ultra-widefield color, and autofluorescent fundus photographies to assess the ocular involvement.
Patient's best-corrected visual acuity was of 20/25 in the right eye and 20/20 in the left eye. Fundus appearance showed abnormal yellowish choroidal lesions and moderate vitritis in both eyes. Fluorescein angiography was within normal limits, whereas indocyanine green angiography showed areas of choroiditis in both eyes, and structural optical coherence tomography scans disclosed retinal small roundish lesions in the corresponding regions. Laboratory examinations and lymph node biopsy led to the final diagnosis of immunoglobulin G4-related disease.
We describe a case of immunoglobulin G4-related choroiditis mimicking intraocular lymphoma. The proper use of multimodal imaging associated with laboratory investigations was helpful to reach the correct diagnosis.
描述一例疑似眼内淋巴瘤的免疫球蛋白G4相关性脉络膜炎病例。
患者接受了包括多模态成像在内的全面眼科评估，采用结构光学相干断层扫描、荧光素血管造影、吲哚菁绿血管造影、超广角彩色和自发荧光眼底照相来评估眼部受累情况。
患者右眼最佳矫正视力为20/25，左眼为20/20。眼底表现为双眼黄斑部脉络膜病变异常及中度玻璃体炎。荧光素血管造影结果正常，而吲哚菁绿血管造影显示双眼脉络膜炎区域，结构光学相干断层扫描在相应区域发现视网膜小圆形病变。实验室检查和淋巴结活检最终确诊为免疫球蛋白G4相关性疾病。
我们描述了一例疑似眼内淋巴瘤的免疫球蛋白G4相关性脉络膜炎病例。正确使用多模态成像并结合实验室检查有助于做出正确诊断。
