*National Eye Institute, National Institutes of Health, Bethesda, Maryland; and †Associated Retinal Consultants, P.C., Royal Oak, Michigan.
Retina. 2014 Feb;34(2):366-72. doi: 10.1097/IAE.0b013e31829977fa.
To evaluate fundus autofluorescence (FAF) patterns in patients with primary intraocular (vitreoretinal) lymphoma.
Records of all patients with primary intraocular lymphoma who underwent FAF imaging at the National Eye Institute were reviewed. Fundus autofluorescence patterns were evaluated with respect to clinical disease status and the findings on fluorescein angiography and spectral-domain optical coherence tomography.
There were 18 eyes (10 patients) with primary intraocular lymphoma that underwent FAF imaging. Abnormal autofluorescence in the form of granular hyperautofluorescence and hypoautofluorescence was seen in 11 eyes (61%), and blockage by mass lesion was seen in 2 eyes (11%). All eyes with granular pattern on FAF had active primary intraocular lymphoma at the time of imaging, but there were 5 eyes with unremarkable FAF, which were found to have active lymphoma. The most common pattern on fluorescein angiography was hypofluorescent round spots with a "leopard spot" appearance (43%). These hypofluorescent spots on fluorescein angiography correlated with hyperautofluorescent spots on FAF in 5 eyes (36%) (inversion of FAF). Nodular hyperreflective spots at the level of retinal pigment epithelium on optical coherence tomography were noted in 43% of eyes. The hyperautofluorescent spots on FAF correlated with nodular hyperreflective spots on optical coherence tomography in 6 eyes (43%).
Granularity on FAF was associated with active lymphoma in majority of the cases. An inversion of FAF (hyperautofluorescent spots on FAF corresponding to hypofluorescent spots on fluorescein angiography) was observed in less than half of the eyes.
评估原发性眼内（玻璃体视网膜）淋巴瘤患者的眼底自发荧光（FAF）模式。
回顾了在国立眼科研究所接受 FAF 成像检查的所有原发性眼内淋巴瘤患者的记录。根据临床疾病状态以及荧光素血管造影和频域光相干断层扫描的结果，评估 FAF 模式。
共有 18 只眼（10 例）进行了 FAF 成像的原发性眼内淋巴瘤患者。11 只眼（61%）出现了颗粒状高自发荧光和低自发荧光的异常自发荧光，2 只眼（11%）出现了肿块病变的阻塞。所有 FAF 呈颗粒状的眼均在成像时存在活动性原发性眼内淋巴瘤，但有 5 只眼的 FAF 无明显异常，却发现存在活动性淋巴瘤。荧光素血管造影最常见的模式是低荧光圆形斑点伴“豹斑”外观（43%）。荧光素血管造影上这些低荧光斑点与 FAF 上的高自发荧光斑点在 5 只眼（36%）中（FAF 反转）相关。光学相干断层扫描在视网膜色素上皮水平上发现了 43%的结节性高反射性斑点。FAF 上的高自发荧光斑点与光学相干断层扫描上的结节性高反射性斑点在 6 只眼（43%）中相关。
FAF 的颗粒状与大多数情况下的活动性淋巴瘤相关。不到一半的眼观察到 FAF 反转（FAF 上的高自发荧光斑点对应于荧光素血管造影上的低荧光斑点）。
