Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Tomioka, Urayasu, Chiba 279-0021, Japan.
Anti-Aging Skin Research Laboratory, Juntendo University Graduate School of Medicine, 2-1-1 Tomioka, Urayasu, Chiba 279-0021, Japan.
Int J Mol Sci. 2020 Nov 9;21(21):8406. doi: 10.3390/ijms21218406.
Itch (or pruritus) was not previously recognized as a serious symptom of psoriasis. However, approximately 60-90% of psoriatic patients with pruritus have stated that it deteriorates their quality of life. Since conventional antipruritic therapies, such as antihistamines, only exert limited effects, the establishment of a treatment option for itch in psoriasis is urgently needed. Although a definitive drug is not currently available, various itch mediators are known to be involved in pruritus in psoriasis. In this review, we describe the clinical features of pruritus in psoriasis, classify a wide range of itch mediators into categories, such as the nervous, immune, endocrine, and vascular systems, and discuss the mechanisms by which these mediators induce or aggravate itch in the pathophysiology of psoriasis.
瘙痒（或瘙痒症）以前并未被认为是银屑病的严重症状。然而，约 60-90%的伴有瘙痒的银屑病患者表示，它降低了他们的生活质量。由于传统的止痒疗法，如抗组胺药，仅能发挥有限的作用，因此迫切需要为银屑病的瘙痒建立一种治疗选择。尽管目前尚无明确的药物，但已知各种瘙痒介质参与了银屑病的瘙痒。在这篇综述中，我们描述了银屑病瘙痒的临床特征，将广泛的瘙痒介质分类为神经系统、免疫系统、内分泌系统和血管系统等类别，并讨论了这些介质在银屑病病理生理学中引起或加重瘙痒的机制。
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