Medical College of Georgia, Augusta University, Augusta, GA, USA.
College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
J Dermatolog Treat. 2020 Feb;31(1):18-26. doi: 10.1080/09546634.2019.1572865. Epub 2019 Jul 5.
Pruritus, a very broad, subjective, and complex symptom, troubles the majority of patients with psoriasis. However, the subjective and multidimensional nature of the symptom renders it challenging for patients to appropriately communicate their experiences with itch to providers. This review explores current perspectives regarding the underlying mechanisms, assessment tools, burden, and treatment modalities for psoriatic pruritus. It emphasizes the significance of incorporating a standardized, thorough, and verified metric that incorporates severity, distribution, and character of pruritus as well as its effects on various aspects of quality of life. It also underscores the importance of continued research to fully understand the pathogenesis of psoriatic itch for establishment of novel, targeted therapeutics.
瘙痒是一种非常广泛、主观和复杂的症状,困扰着大多数银屑病患者。然而,由于症状的主观性和多维性质,患者难以向提供者恰当地传达他们的瘙痒体验。本综述探讨了目前关于银屑病瘙痒的潜在机制、评估工具、负担和治疗方式的观点。它强调了采用标准化、全面和经过验证的指标的重要性,该指标应包括瘙痒的严重程度、分布和特征以及其对生活质量各个方面的影响。它还强调了继续研究以充分了解银屑病瘙痒的发病机制,从而为新型靶向治疗方法的确立的重要性。