Allergy and Clinical Immunology Unit, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.
Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Eur Ann Allergy Clin Immunol. 2021 Sep;53(5):201-208. doi: 10.23822/EurAnnACI.1764-1489.177. Epub 2020 Nov 12.
T cells are coordinators of the immune response and have been shown to play a central role in the pathophysiology of asthma. A good understanding of the T cells functions in asthma is important for therapeutic reasons, in particular for the choice of biological treatments in severe asthma. Although classically considered a Th2 disease, it is now clear that other types of T cells contribute for the pathophysiology and the heterogeneity of asthma. We here review how the different subsets of T cells are involved in the different phenotypes/endotypes of asthma and how this may influence the treatment of the disease.
T 细胞是免疫反应的协调者，已被证明在哮喘的病理生理学中发挥核心作用。深入了解 T 细胞在哮喘中的功能对于治疗具有重要意义，特别是对于严重哮喘的生物治疗选择。尽管经典上被认为是 Th2 疾病，但现在很清楚，其他类型的 T 细胞也有助于哮喘的病理生理学和异质性。我们在此回顾了不同 T 细胞亚群如何参与不同表型/内型的哮喘，以及这可能如何影响疾病的治疗。
