Department of Pediatrics, Division of Infectious Diseases, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Immun Inflamm Dis. 2022 Nov;10(11):e726. doi: 10.1002/iid3.726.
Chlamydia pneumoniae (C. pneumoniae) is a gram-negative intracellular bacterium that causes respiratory infection in humans, including subjects with or without asthma. C. pneumoniae activates cells (e.g., monocytes/macrophages) in vitro, and produces cytokines that may contribute to inflammatory responses observed in asthma. Immunological differences exist between subjects with or without asthma, with regard to host responses to C. pneumoniae. The heterogeneity and subsequent diverse pathophysiology of asthma can be better understood by analyzing the repertoire of T-cell subpopulations; the most common distinction between different asthma endotypes includes cytokines produced by CD4 cells (T helper (Th)2 high vs. Th2 low).
肺炎衣原体（C. pneumoniae）是一种革兰氏阴性的细胞内细菌，可引起人类呼吸道感染，包括有或没有哮喘的患者。C. pneumoniae 在体外激活细胞（例如单核细胞/巨噬细胞），并产生细胞因子，这些细胞因子可能有助于哮喘中观察到的炎症反应。对于有或没有哮喘的患者，宿主对 C. pneumoniae 的反应存在免疫差异。通过分析 T 细胞亚群的 repertoire，可以更好地理解哮喘的异质性和随后的不同病理生理学；不同哮喘表型之间最常见的区别包括 CD4 细胞产生的细胞因子（Th2 高与 Th2 低）。
