Department of Urology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
J Nanosci Nanotechnol. 2021 Feb 1;21(2):955-961. doi: 10.1166/jnn.2021.18638.
Bladder tumor is a malignant tumor on bladder mucosa and the most common malignant tumor of urinary system. At present, bladder cancer is mainly treated by surgical resection and intravesical infusion of anticancer drugs. The high-molecular nano-drug-loading system has the advantages of direct focus of the drug in the treatment of cancer, reduced systemic toxicity and high local concentration. The purpose of this paper was to study the effect of polymer nano-drug loading system on bladder cancer perfusion. The synthesized polymer was applied to the establishedmouse bladder cancer model, the anticancer effect of polymer nano-drug loading system on mice in vivo was observed, and the health status of mice during administration was determined. It was found that a large number of drugs could adhere to the tumor tissue after perfusion of bladder cancer with polymer nano-drug loading system, and the effect of killing bladder cancer cells was better.
膀胱癌是一种发生在膀胱黏膜上的恶性肿瘤，也是泌尿系统最常见的恶性肿瘤。目前膀胱癌主要通过手术切除和膀胱内灌注抗癌药物进行治疗。高分子纳米药物载药系统具有使药物在治疗癌症时直接聚焦、降低全身毒性和提高局部浓度的优点。本文旨在研究聚合物纳米药物载药系统对膀胱癌灌注的影响。合成的聚合物被应用于建立的小鼠膀胱癌模型中，观察聚合物纳米药物载药系统对体内小鼠的抗癌作用，并确定给药期间小鼠的健康状况。结果发现，聚合物纳米药物载药系统灌注膀胱癌后，大量药物可附着在肿瘤组织上，对膀胱癌细胞的杀伤效果更好。
