基于纳米碳混悬液示踪染色技术对口腔鳞状细胞癌患者的影响。
Effect of Tracer Staining Technology Based on Nano-Carbon Suspension on Patients with Oral Squamous Cell Carcinoma.
机构信息
Department of Stomatology, First People's Hospital of Lianyungang, No. 182 Tongguan North Road, Lianyungang, Jiangsu Province, 222000, China.
Department of Stomatology, Lianyungang Municipal Oriental Hospital, No. 57 Zhonghua West Road, Lianyungang, Jiangsu Province, 222000, China.
出版信息
J Nanosci Nanotechnol. 2021 Feb 1;21(2):995-1000. doi: 10.1166/jnn.2021.18702.
Oral squamous cell carcinoma has the characteristics of high malignancy, strong invasiveness and special anatomical location. The prognosis of patients is generally poor. Invasion and metastasis of oral squamous cell carcinoma is a complex process involving multiple levels and factors. In order to explore the value of sentinel lymph node biopsy tracked by nano-carbon suspension in the treatment of early oral squamous cell carcinoma, 58 patients with early oral squamous cell carcinoma were selected in this paper. The pathological results of sentinel lymph nodes were analyzed after operation. In this study, the detection rate, sensitivity, accuracy, and false negative rate of the sentinel lymph nodes with the nano-carbon suspension were 95.6%, 86.4%, 92.2%, and 11.4%, respectively. The results show that sentinel lymph node biopsy traced by nano-carbon suspension has certain application value in guiding the treatment of early oral squamous cell carcinoma.
口腔鳞状细胞癌具有恶性程度高、侵袭性强、解剖位置特殊等特点，患者的预后一般较差。口腔鳞状细胞癌的侵袭和转移是一个涉及多个层次和因素的复杂过程。为了探讨纳米碳混悬液示踪前哨淋巴结活检在早期口腔鳞状细胞癌治疗中的价值，本研究选取了 58 例早期口腔鳞状细胞癌患者，对术后前哨淋巴结的病理结果进行了分析。本研究中，纳米碳混悬液示踪的前哨淋巴结检测率、灵敏度、准确率、假阴性率分别为 95.6%、86.4%、92.2%、11.4%。结果表明，纳米碳混悬液示踪的前哨淋巴结活检在指导早期口腔鳞状细胞癌的治疗中有一定的应用价值。
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