Department of Neurology, Taishan Hospital of Shandong Province, Taian, 271000, Shandong Province, China.
Department of Neurology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
J Nanosci Nanotechnol. 2021 Feb 1;21(2):1176-1183. doi: 10.1166/jnn.2021.18636.
Parkinson's disease is a degenerative disease of the central nervous system, and it occurs in middle-aged and elderly people. Studies have shown that both the clinical symptoms and neuropathological evidence of Parkinson's disease suggest that Parkinson's disease may originate in the gut. Intestinal flora homeostasis plays an important role in maintaining normal functions of the brain and nervous system. It participates in changes in cellular flora through oxidative stress, inflammatory response, and immune response during metabolism. Intestinal flora disorders are closely related to the onset of neurological diseases such as Parkinson's disease (PD). In order to better understand the relationship between intestinal flora and Parkinson's disease, this article studies the correlation between PD rat models and intestinal flora, and analyzes the possible relationship between them. The 6-OHDA PD rat model is currently a better model preparation method, which is widely used in PD research. The experimental results show that using Fe₃O₄ nanoparticle technology to detect intestinal flora disorders in PD patients, and the role of intestinal flora disorders in Parkinson's disease may include affecting inflammatory response and oxidative stress, -synuclein Protein (-syn), these modes of action are not independent, there are complex and synergistic effects, and the molecular simulation mechanism may play a key role in these effects. There is a certain relationship between intestinal flora and Parkinson's disease, but the specific mechanism is not clear, and further research is needed to provide more directions for the early diagnosis and early treatment of PD.
帕金森病是一种中枢神经系统退行性疾病，多发于中老年人。研究表明，帕金森病的临床症状和神经病理学证据都提示帕金森病可能起源于肠道。肠道菌群稳态对维持大脑和神经系统的正常功能起着重要作用。它通过代谢过程中的氧化应激、炎症反应和免疫反应参与细胞菌群的变化。肠道菌群紊乱与帕金森病等神经疾病的发病密切相关。为了更好地了解肠道菌群与帕金森病的关系，本文研究了 PD 大鼠模型与肠道菌群的相关性，并分析了它们之间可能存在的关系。目前，6-OHDA PD 大鼠模型是一种较好的模型制备方法，广泛应用于 PD 研究。实验结果表明，采用 Fe₃O₄ 纳米粒子技术检测 PD 患者肠道菌群紊乱，肠道菌群紊乱在帕金森病中的作用可能包括影响炎症反应和氧化应激、-突触核蛋白（-syn）等，这些作用方式不是独立的，存在复杂的协同作用，分子模拟机制可能在这些作用中起关键作用。肠道菌群与帕金森病之间存在一定的关系，但具体机制尚不清楚，需要进一步研究为 PD 的早期诊断和早期治疗提供更多方向。
