Xu Ke, Bai Yan, Wang Yu-Lin, Li Yuan, Wang Shun
The Second Clinical Medical School of Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Institute of Acupuncture and Moxibustion, Heilongjiang Academy of Traditional Chinese Medicine, Harbin 150000.
Zhen Ci Yan Jiu. 2024;49(9):985-992. doi: 10.13702/j.1000-0607.20230094.
Parkinson's disease (PD) is a neurodegenerative disease commonly seen in middle-aged and elderly people. The incidence of PD is increasing year by year, which seriously affects the patients' quality of life. Oxidative stress (OS) is one of the pathogeneses of PD. In recent years, with the deepening of research, it has been found that OS is closely related to other PD-related pathogenesis, such as the susceptibility of substantia nigra, mitochondrial dysfunction, abnormal folding of α -synuclein (α -Syn), nitric oxide (NO) increasing, endoplasmic reticulum stress (ERS), decreased antioxidant capacity, etc., which is considered to be the central link of the complex convergence of various pathogenesis. A large number of studies also have shown that acupuncture has great potential in regulating OS and treatment of PD. In the present article, we reviewed the role of OS in PD pathology and the mechanism of acupuncture in the treatment of PD by improving OS in recent years： 1) acupuncture acts on Parkinson's disease by increasing antioxidant enzyme levels, 2) acupuncture works in Parkinson's disease by improving pathways related to OS (Nrf2/ARE, PI3K/Akt), 3) acupuncture acts on Parkinson's disease by improving OS-related neuroinflammation, and 4) acupuncture acts on Parkinson's disease by improving the cerebral-intestinal axis associated oxidative stress.
帕金森病（PD）是一种常见于中老年人的神经退行性疾病。PD的发病率逐年上升，严重影响患者的生活质量。氧化应激（OS）是PD的发病机制之一。近年来，随着研究的深入，发现OS与其他PD相关发病机制密切相关，如黑质易感性、线粒体功能障碍、α-突触核蛋白（α-Syn）异常折叠、一氧化氮（NO）增加、内质网应激（ERS）、抗氧化能力下降等，被认为是各种发病机制复杂汇聚的中心环节。大量研究还表明，针灸在调节OS和治疗PD方面具有巨大潜力。在本文中，我们综述了近年来OS在PD病理中的作用以及针灸通过改善OS治疗PD的机制：1）针灸通过提高抗氧化酶水平作用于帕金森病；2）针灸通过改善与OS相关的信号通路（Nrf2/ARE、PI3K/Akt）治疗帕金森病；3）针灸通过改善与OS相关的神经炎症作用于帕金森病；4）针灸通过改善脑-肠轴相关的氧化应激作用于帕金森病。
