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纳米气泡肺部超声在新生儿肺炎治疗中的应用。

Nanobubble Lung Ultrasound Application in the Treatment of Neonatal Pneumonia.

机构信息

Department of Ultrasonic, The Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, 157009, China.

Department of Anesthesiology, The Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, 157009, China.

出版信息

J Nanosci Nanotechnol. 2021 Feb 1;21(2):1244-1249. doi: 10.1166/jnn.2021.18693.

DOI:10.1166/jnn.2021.18693
PMID:33183468
Abstract

This article studies the effect of pulmonary ultrasound in the diagnosis and treatment of neonatal pneumonia. In this experiment, 33 children with pneumonia diagnosed and treated in the hospital were selected as the research objects, and all were performed by X-ray examination and lung ultrasound. After the test was completed, the diagnostic accuracy of the two examination methods was analyzed, the performance of the chest X-rays of the children were observed, and the lung ultrasound examination was recorded at the same time. The results showed that the diagnostic accuracy of lung ultrasound examination was 93.00%, which was higher than 75.00% of X-ray examination, and the difference was statistically significant ( < 0.05). In the experiment, the paired chi-square test was performed on the results of LUS and bedside CXR diagnosis of IPN, and the value was 0.687. The two have a good consistency in the diagnosis of IPN in NICU. The Pearson correlation test results of LUS score and neonatal pneumonia case score showed that there was a significant negative correlation between LUS score and neonatal pneumonia case score. The LUS scores between the control group, non-risk recombination, and risk recombination were tested by rank sum test of multiple independent samples. The results showed that the LUS scores of the three groups were statistically significant ( < 0.05). The LUS scores of the risk recombination were significantly higher than the non-risk recombination. Two independent sample rank sum tests were performed between each two groups. After Bonferroni correction of value, the difference between each group was statistically significant. In the end, we have concluded that for the diagnosis of neonatal pneumonia, pulmonary ultrasound can be used for diagnosis. Combining pulmonary ultrasound with X-rays can improve the diagnosis accuracy of pneumonia. During the treatment, ultrasound is used for dynamic monitoring. By observing the pleural line and pulmonary consolidation it can be used to clarify the treatment effect of children. LUS and bedside CXR have a good agreement for the diagnosis of IPN. The LUS score can effectively assess the severity of IPN. The greater the severity of the disease in children with IPN, the higher the LUS score.

摘要

这篇文章研究了肺部超声在新生儿肺炎的诊断和治疗中的作用。在这项实验中,选择了 33 名在医院诊断和治疗的肺炎患儿作为研究对象,均进行 X 线检查和肺部超声检查。试验完成后,分析了两种检查方法的诊断准确率,观察了患儿的胸部 X 线表现,同时记录肺部超声检查结果。结果显示,肺部超声检查的诊断准确率为 93.00%,高于 X 线检查的 75.00%,差异有统计学意义(<0.05)。在实验中,对 LUS 和床边 CXR 对 IPN 的诊断结果进行配对卡方检验,值为 0.687。两种方法在 NICU 中对 IPN 的诊断一致性较好。LUS 评分与新生儿肺炎病例评分的 Pearson 相关性检验结果表明,LUS 评分与新生儿肺炎病例评分呈显著负相关。采用多个独立样本秩和检验对对照组、非风险重组和风险重组的 LUS 评分进行检验。结果表明,三组 LUS 评分差异有统计学意义(<0.05)。风险重组的 LUS 评分明显高于非风险重组。对每组进行两两独立样本秩和检验。在对 值进行 Bonferroni 校正后,每组间差异有统计学意义。最后得出结论,对于新生儿肺炎的诊断,肺部超声可用于诊断。肺部超声与 X 射线结合可提高肺炎的诊断准确率。在治疗中,利用超声进行动态监测,通过观察肋膈角和肺实变情况,可明确儿童的治疗效果。LUS 和床边 CXR 对 IPN 的诊断具有良好的一致性。LUS 评分能有效评估 IPN 的严重程度,肺炎患儿的病情越重,LUS 评分越高。

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