Department of Intensive Care Unit, The Second Affiliated Hospital, University of South China, Hengyang 421001, China.
J Nanosci Nanotechnol. 2021 Feb 1;21(2):1286-1292. doi: 10.1166/jnn.2021.18663.
High-fat pancreatitis and hyperlipidemia refer to disorders of blood lipid metabolism caused by abnormally elevated blood lipids, and are risk factors for high-risk diseases such as atherosclerosis, coronary heart disease, and cerebral infarction. Hyperlipidemia is also a common disease that is common in modern people, and has a tendency to become younger. In this paper, probucol is made into a self-assembled probucol loaded nanosuspensions (SPN) using molecular selfassembly technology for research on improving its oral absorption. The main research contents include: preparation, prescription screening and characterization of physicochemical properties of SPN nanosuspensions; study of SPN intestinal cell uptake and dynamic behavior; research on the mechanism of SPN improving oral absorption of probucol and its gastrointestinal Preliminary Evaluation of Physiological Safety. And by using the method of intraperitoneal injection of SPN to interfere with the retrograde bile duct injection of SPN in the hyperlipidemia model, to make hyperlipidemia combined with severe acute pancreatitis to observe the severity of pancreatitis and lung injury; discuss the protective effect of SPN on hyperlipidemia combined with severe acute pancreatitis with lung injury and its mechanism.
高脂性胰腺炎和高脂血症是指由于血脂异常升高而引起的血脂代谢紊乱，是动脉粥样硬化、冠心病、脑梗死等高危疾病的危险因素。高脂血症也是一种常见的现代疾病，且有年轻化的趋势。本文采用分子自组装技术，将普罗布考制成自组装普罗布考载纳米混悬剂（SPN），研究其改善口服吸收的作用。主要研究内容包括：SPN 纳米混悬剂的制备、处方筛选和理化性质表征；SPN 肠细胞摄取和体内动态行为研究；SPN 提高普罗布考口服吸收的作用机制及其胃肠道初步生理安全性评价。并通过采用 SPN 腹腔注射的方法干扰 SPN 逆行胆管注射的高脂血症模型，使高脂血症合并重症急性胰腺炎，观察胰腺炎和肺损伤的严重程度；探讨 SPN 对高脂血症合并重症急性胰腺炎肺损伤的保护作用及其机制。
