Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Nutrition. 2021 Feb;82:111024. doi: 10.1016/j.nut.2020.111024. Epub 2020 Sep 18.
Many treatment modalities have been used to manage psoriasis; however, there is, to our knowledge, no pooled estimate for the effectiveness of oral vitamin D supplements in patients with psoriasis. Hence, the aim of the present study was to systematically review and meta-analyze the efficacy of oral vitamin D supplementation in lessening disease severity of patients with psoriasis.
A systematic literature review was performed on the electronic databases PubMed, Embase, and Cochrane Central and the gray literature for retrieving randomized controlled trials comparing oral vitamin D supplementation with placebo. The primary outcome was the change of Psoriasis Area and Severity Index (PASI) score. We used the random effects model for synthesizing the evidence.
Of the total 5018 search results, 4 studies were included in the qualitative and 3 studies in quantitative analysis. Vitamin D supplementation was effective in ameliorating the PASI score after 6 mo of intervention (mean difference [MD] = -0.92, 95% confidence interval [CI] = -1.72 to -0.11). However, after the Hartung-Knapp adjustment, the results became non-significant (MD = -0.92, 95% CI = -2.21 to 0.38).
A favorable effect of oral vitamin D supplementation in patients with psoriasis could not be verified. More randomized controlled trials with larger sample sizes are needed to produce robust results.
已有多种治疗方法用于治疗银屑病，但据我们所知，尚无关于口服维生素 D 补充剂治疗银屑病患者有效性的汇总估计。因此，本研究旨在系统评价和荟萃分析口服维生素 D 补充剂减轻银屑病患者疾病严重程度的疗效。
我们在电子数据库 PubMed、Embase 和 Cochrane Central 以及灰色文献中进行了系统文献检索，以检索比较口服维生素 D 补充剂与安慰剂的随机对照试验。主要结局是银屑病面积和严重程度指数（PASI）评分的变化。我们使用随机效应模型对证据进行综合。
在总共 5018 项搜索结果中，有 4 项研究纳入定性分析，3 项研究纳入定量分析。维生素 D 补充剂在干预 6 个月后可有效改善 PASI 评分（平均差异 [MD] = -0.92，95%置信区间 [CI] = -1.72 至 -0.11）。然而，经过 Hartung-Knapp 调整后，结果变得无统计学意义（MD = -0.92，95% CI = -2.21 至 0.38）。
不能证实口服维生素 D 补充剂对银屑病患者有良好的疗效。需要更多样本量更大的随机对照试验来得出可靠的结果。
