Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Department of Biology of Cytoskeleton, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Life Sci Alliance. 2020 Nov 12;4(1). doi: 10.26508/lsa.202000655. Print 2021 Jan.
Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation.
肌动蛋白调节蛋白 1 是一种关键的肌动蛋白调节蛋白，与单体肌动蛋白和几种肌动蛋白结合蛋白相互作用，控制肌动蛋白聚合。最近，人们已经清楚地认识到这种肌动蛋白同工型通过形成蛋白与微管结合，并干扰细胞外周的微管伸长。例如，在细胞边缘进行广泛的肌动蛋白聚合时，募集与微管相关的肌动蛋白调节蛋白会增强微管的生长，这表明肌动蛋白调节蛋白有助于协调肌动蛋白和微管组织。在这里，我们通过证明它也在中心体中发挥作用，影响微管的核形成，进一步提供了肌动蛋白调节蛋白与微管连接的证据。
