Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea.
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea.
Sci Rep. 2020 Nov 12;10(1):19672. doi: 10.1038/s41598-020-76777-w.
The general disease burden associated with the restrictive spirometric pattern (RSP) is substantial. However, the impact of RSP by its severity on general health problems and quality of life has not been well elucidated. This study aimed to analyse nutrition, physical activity, and quality of life in subjects who participated in the Korea National Health and Nutrition Examination Survey 2007-2016 according to severity of RSP. Participants were classified as subjects with normal spirometry, those with mild-to-moderate RSP, and those with severe RSP. Poor quality of life was defined as 25th percentile value on the EuroQoL five dimensions (Eq5D) questionnaire index, i.e., 0.90. This study included 23,615 subjects composed of 20,742 with normal spirometry, 2758 with mild-to-moderate RSP, and 115 with severe RSP. The subjects with severe RSP were more likely to have attained lower education levels, had a lower total caloric intake, had less physical activity, had experienced a higher prevalence of comorbidities, and poorer quality of life than those with normal spirometry (P < 0.001 for all). In multivariable analysis, subjects with a mild-to-moderate RSP and severe RSP were more likely to show decreased total calories (coefficient for change in calorie = - 56.6 kcal and - 286.7 kcal, respectively) than those with normal spirometry; subjects with mild-to-moderate RSP and those with severe RSP were 1.26 times and 1.96 times more likely, respectively, to have a poorer quality of life than those with normal spirometry. Additionally, subjects with mild-to-moderate RSP and those with severe RSP were 0.84 times and 0.36 times less likely, respectively, to have high-intensity physical activity than those with normal spirometry in univariable analysis. The trends of a poorer quality of life and physical activity were only significant in the male subgroups. In conclusion, our study revealed that the severity of general health problems and quality of life reductions are correlated with the severity of RSP, especially in males.
与限制性肺量测定模式（RSP）相关的一般疾病负担相当大。然而，RSP 严重程度对一般健康问题和生活质量的影响尚未得到充分阐明。本研究旨在分析 2007-2016 年参加韩国国家健康和营养检查调查的受试者中根据 RSP 严重程度的营养、身体活动和生活质量。参与者被分为正常肺量测定组、轻度至中度 RSP 组和重度 RSP 组。生活质量差定义为 EuroQoL 五维（Eq5D）问卷指数的第 25 百分位值，即 0.90。本研究共纳入 23615 名受试者，其中 20742 名受试者肺量测定正常，2758 名受试者轻度至中度 RSP，115 名受试者重度 RSP。与肺量测定正常者相比，重度 RSP 患者更有可能接受较低水平的教育，总热量摄入较低，身体活动较少，合并症患病率较高，生活质量较差（所有 P<0.001）。多变量分析显示，与肺量测定正常者相比，轻度至中度 RSP 组和重度 RSP 组的总热量摄入减少（热量变化的系数分别为-56.6 kcal 和-286.7 kcal）；与肺量测定正常者相比，轻度至中度 RSP 组和重度 RSP 组生活质量较差的可能性分别增加 1.26 倍和 1.96 倍。此外，与肺量测定正常者相比，轻度至中度 RSP 组和重度 RSP 组高强度身体活动的可能性分别降低 0.84 倍和 0.36 倍。在单变量分析中，仅在男性亚组中观察到生活质量和身体活动较差的趋势具有统计学意义。总之，本研究表明，一般健康问题严重程度和生活质量降低与 RSP 严重程度相关，尤其是在男性中。
