Yang Bumhee, Choi Hayoung, Shin Sun Hye, Kim Youlim, Moon Ji-Yong, Park Hye Yun, Lee Hyun
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju 28644, Korea.
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul 07441, Korea.
J Pers Med. 2021 Jul 19;11(7):678. doi: 10.3390/jpm11070678.
Tuberculosis (TB) survivors experience post-TB lung damage and ventilatory function disorders. However, the proportions of obstructive and restrictive ventilatory disorders as well as normal ventilation among subjects with prior TB are unknown. In addition, the impacts of ventilatory disorder and its severity on respiratory symptoms, physical activity limitations, and the quality of life in subjects with prior TB remain unclear. Subjects who participated in the Korean National Health and Nutritional Examination Survey 2007-2016 were enrolled in this study. We evaluated the impact of each ventilatory disorder and its severity on respiratory symptoms, physical activity limitations, and quality of life (measured by the EuroQoL five dimensions questionnaire [EQ-5D] index values) in subjects with prior TB. Among 1466 subjects with prior TB, 29% and 16% had obstructive ventilatory disorders and restrictive ventilatory disorders, respectively. Mild and moderate obstructive ventilatory disorders were not associated with respiratory symptoms, physical activity limitations, or EQ-5D index value compared with normal ventilation; however, severe obstructive ventilatory disorders were associated with more respiratory symptoms (adjusted odds ratio [aOR] = 13.62, 95% confidence interval [CI] = 4.64-39.99), more physical activity limitation (aOR = 218.58, 95% CI = 26.82-1781.12), and decreased EQ-5D index (adjusted coefficient = -0.06, 95% CI = (-0.12--0.10) compared with normal ventilation. Mild restrictive ventilatory disorders were associated with more respiratory symptoms (aOR = 2.10, 95% CI = 1.07-4.14) compared with normal ventilation, while moderate (aOR = 5.71, 95% CI = 1.14-28.62) and severe restrictive ventilatory disorders (aOR = 9.17, 95% CI = 1.02-82.22) were associated with physical activity limitation compared with normal ventilation. In conclusion, among subjects with prior TB, 29% and 16% developed obstructive and restrictive ventilatory disorders, respectively. Severe obstructive ventilatory disorder was associated with more respiratory symptoms, more physical activity limitation, and poorer quality of life, while severe restrictive ventilatory disorder was associated with more physical activity limitations.
肺结核（TB）幸存者会经历肺结核后的肺部损伤和通气功能障碍。然而，既往患肺结核的受试者中阻塞性和限制性通气障碍以及通气正常的比例尚不清楚。此外，通气障碍及其严重程度对既往患肺结核受试者的呼吸道症状、身体活动受限情况和生活质量的影响仍不明确。本研究纳入了参加2007 - 2016年韩国国民健康与营养检查调查的受试者。我们评估了每种通气障碍及其严重程度对既往患肺结核受试者的呼吸道症状、身体活动受限情况和生活质量（通过欧洲五维健康量表[EQ - 5D]指数值衡量）的影响。在1466名既往患肺结核的受试者中，分别有29%和16%患有阻塞性通气障碍和限制性通气障碍。与通气正常相比，轻度和中度阻塞性通气障碍与呼吸道症状、身体活动受限情况或EQ - 5D指数值无关；然而，重度阻塞性通气障碍与更多的呼吸道症状（调整优势比[aOR]=13.62，95%置信区间[CI]=4.64 - 39.99）、更多的身体活动受限（aOR = 218.58，95% CI = 26.82 - 1781.12）以及EQ - 5D指数降低（调整系数=-0.06，95% CI = (-0.12 - -0.10)）相关。与通气正常相比，轻度限制性通气障碍与更多的呼吸道症状（aOR = 2.10，95% CI = 1.07 - 4.14）相关，而中度（aOR = 5.71，9�% CI = 1.14 - 28.62）和重度限制性通气障碍（aOR = 9.17，95% CI = 1.02 - 82.22）与身体活动受限相关。总之，在既往患肺结核的受试者中，分别有29%和16%出现了阻塞性和限制性通气障碍。重度阻塞性通气障碍与更多的呼吸道症状、更多的身体活动受限和更差的生活质量相关，而重度限制性通气障碍与更多的身体活动受限相关。
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