Palmer R H
Columbia University College of Physicians and Surgeons, New York, New York.
Am J Med. 1987 Nov 27;83(5B):37-43. doi: 10.1016/0002-9343(87)90869-2.
Fenofibrate, a potent analogue of clofibrate, causes changes in biliary lipid composition similar to those seen with clofibrate and other derivatives of fibric acid, although there is a suggestion that the increase in cholesterol content may be accompanied by an increase in phospholipid content as well as a decrease in bile acid content. This may favor liquid crystal formation, and fenofibrate may have less propensity to cause gallstones than would other derivatives. Many other factors are also important in determining whether supersaturated bile will result in gallstone formation, and the use of this compound should be monitored in the future to determine the clinical importance of these findings.
非诺贝特是氯贝丁酯的一种强效类似物，它引起的胆汁脂质成分变化与氯贝丁酯及其他纤维酸衍生物相似，不过有迹象表明，胆固醇含量增加的同时可能伴随着磷脂含量的增加以及胆汁酸含量的减少。这可能有利于液晶形成，并且与其他衍生物相比，非诺贝特导致胆结石的倾向可能较小。在决定过饱和胆汁是否会导致胆结石形成方面，许多其他因素也很重要，未来应对该化合物的使用进行监测，以确定这些发现的临床重要性。
