CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telangana, 500007, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Transgenic Res. 2020 Dec;29(5-6):553-562. doi: 10.1007/s11248-020-00219-6. Epub 2020 Nov 13.
Disco-interacting protein 2 is a highly conserved three-domain protein with two tandem Adenylate-forming domains. It is proposed to influence the processes involved in neuronal development by influencing lipid metabolism and remains to be characterized. In this study, we show that Disco-interacting protein 2a null mice do not exhibit overt phenotype defects. However, the body composition differences were observed in these mice under different dietary regimens. The neutral lipid composition of two different diets was characterized, and it was observed that the new-born mice grow relatively slower than the wild-type mice with delayed appearance of features such as dentition when fed with high-triacylglycerol NIN-formulation diet. The high-diacylglycerol Safe-formulation diet was found to accumulate more fat mass in mice than those fed with high-triacylglycerol NIN-formulation diet beyond 10 months. These findings point to a proposed relationship between dietary components (particularly the lipid composition) and body composition along with the growth of neonates in mice lacking the gene Disco-interacting protein 2a.
Disco-interacting protein 2 是一种高度保守的三结构域蛋白，具有两个串联的腺苷酸形成结构域。据推测，它通过影响脂质代谢来影响神经元发育过程，但仍有待进一步研究。在本研究中，我们发现 Disco-interacting protein 2a 缺失小鼠没有明显的表型缺陷。然而，在不同的饮食方案下，这些小鼠的身体成分存在差异。对两种不同饮食的中性脂质组成进行了特征分析，结果发现，与野生型小鼠相比，新生小鼠在喂食高三酰甘油 NIN 配方饮食时生长相对较慢，出现牙齿等特征的时间也较晚。研究发现，与喂食高三酰甘油 NIN 配方饮食的小鼠相比，高二酰甘油 Safe 配方饮食的小鼠在 10 个月后积累了更多的脂肪量。这些发现表明，在缺乏 Disco-interacting protein 2a 基因的小鼠中，饮食成分（特别是脂质组成）与身体成分以及新生儿的生长之间存在一定的关系。
