Lansdown Kate, Jolliffe Katrina A, Salouros Helen
Riverside Corporate Park, National Measurement Institute of Australia, North Ryde, New South Wales, Australia.
School of Chemistry, The University of Sydney, New South Wales, Australia.
Drug Test Anal. 2022 Mar;14(3):496-504. doi: 10.1002/dta.2968. Epub 2020 Dec 14.
Stable isotope ratio mass spectrometry (IRMS) can be used to determine the precursor and precursor origin of methylamphetamine drug samples. Previous work has shown that methylamphetamine samples can be distinguished as derived from different sources of (pseudo)ephedrine or phenyl-2-propanone (P2P) through the use of IRMS alongside conventional chemical profiling techniques. To date, limited research has been conducted to investigate whether methylamphetamine samples of differing P2P origins can be distinguished through drug profiling. This was investigated by synthesising methylamphetamine in-house in a three-step process. Two 'preprecursors' were used in this study, phenylacetic acid (PAA) and α-phenylacetoacetonitrile (α-PAAN). Using a combination of profiling techniques, it was found that methylamphetamine samples of PAA preprecursor origin and methylamphetamine samples of α-PAAN preprecursor origin can be distinguished.
稳定同位素比率质谱分析法（IRMS）可用于确定甲基苯丙胺药物样本的前体及其来源。先前的研究表明，通过将IRMS与传统化学分析技术相结合，甲基苯丙胺样本可被区分为源自不同来源的（伪）麻黄碱或苯基-2-丙酮（P2P）。迄今为止，针对不同P2P来源的甲基苯丙胺样本能否通过药物分析加以区分的研究还很有限。本研究通过三步法在内部合成甲基苯丙胺对此进行了调查。本研究使用了两种“前体前体”，即苯乙酸（PAA）和α-苯基乙酰乙腈（α-PAAN）。通过综合运用分析技术，发现可以区分源自PAA前体前体的甲基苯丙胺样本和源自α-PAAN前体前体的甲基苯丙胺样本。
