[Seroprevalence of and infections among pregnant women in Hangzhou City].

OBJECTIVE

To investigate the prevalence of and infections among pregnant women in Hangzhou City, so as to provide baseline data for decreasing birth defects and improving the population quality.

METHODS

A total of 235 pregnant women receiving prenatal diagnosis at the First People's Hospital of Yuhang District during the period between February 2018 through December 2019 were recruited as the observation group, and 235 age-matched, non-pregnant healthy women at the same hospital during the same period served as the control group. The subjects'medical records were captured from the hospital management information system. Blood samples were collected from the observation and control groups and detected for the presence of IgG antibodies against and using an enzyme-linked immunosorbent assay (ELISA). The seroprevalence of the IgG antibodies against and was compared between the observation and control groups.

RESULTS

The subjects in the observation group had a mean age of 26.5 ± 4.3 years (range, 23 to 31 years), and gestational ages of 10 to 27 weeks, and the subjects in the control group had a mean age of 26.1 ± 5.7 years (range, 20 to 30 years). The seroprevalence rates of IgG antibodies against (28.51% vs. 4.68%; = 34.85, < 0.01) and (24.26% vs. 5.11%; = 25.77, < 0.01) were both significantly higher in the observation group than in the control group, and the seroprevalence of and co-infections was also significantly greater in the observation group than in the control group (13.19% vs. 2.13%; = 17.49, < 0.01).

CONCLUSIONS

The seroprevalence rates of and infections and their co-infections are all high among pregnant women in Hangzhou City. Screening of and infections is strongly recommended during pregnancy.