Meis J F, Jap P H, Hollingdale M R, Verhave J P
Department of Medical Parasitology, University of Nijmegen, The Netherlands.
Am J Trop Med Hyg. 1987 Nov;37(3):506-10. doi: 10.4269/ajtmh.1987.37.506.
Rats were infected with Plasmodium berghei sporozoites, and 47, 51, and 57 hr later exoerythrocytic parasites were examined by electron microscopy. At 47 hr, approximately 30% of nearly mature exoerythrocytic parasites were degenerating and were surrounded by a cellular infiltrate of Kupffer cells, monocytes, monocyte-derived macrophages, and neutrophils. Neutrophils appeared to be actively ingesting electron-dense fuzzy parasite material which was normally present in the parasitophorous vacuole. By 51 hr other mononuclear cells penetrated with filopodia between the host hepatocyte and exoerythrocytic parasite, and directly into the exoerythrocytic parasite. Exoerythrocytic parasites that formed merozoites at 51 hr lacked any notable cellular infiltration.
将大鼠感染伯氏疟原虫子孢子，47、51和57小时后，通过电子显微镜检查红细胞外期寄生虫。在47小时时，近成熟的红细胞外期寄生虫约30%正在退化，并被库普弗细胞、单核细胞、单核细胞衍生的巨噬细胞和中性粒细胞的细胞浸润所包围。中性粒细胞似乎在积极摄取通常存在于寄生泡中的电子致密模糊寄生虫物质。到51小时时，其他单核细胞通过丝状伪足穿透宿主肝细胞和红细胞外期寄生虫之间，并直接进入红细胞外期寄生虫。在51小时形成裂殖子的红细胞外期寄生虫没有任何明显的细胞浸润。
