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1
Characterization of liver lymphomyeloid cells in mice infected with Plasmodium yoelii sporozoites.约氏疟原虫子孢子感染小鼠肝脏淋巴髓样细胞的特征分析。
Immunology. 1994 Aug;82(4):645-50.
2
Plasmodium yoelii in mice: antigen reactivity of CD4- and CD8-bearing T cells.约氏疟原虫在小鼠体内：携带CD4和CD8的T细胞的抗原反应性
Cell Immunol. 1993 Aug;150(1):59-71. doi: 10.1006/cimm.1993.1178.
3
Protracted sterile protection with Plasmodium yoelii pre-erythrocytic genetically attenuated parasite malaria vaccines is independent of significant liver-stage persistence and is mediated by CD8+ T cells.用约氏疟原虫红细胞前期基因减毒寄生虫疟疾疫苗进行的长期无菌保护与显著的肝期持续性无关，且由CD8 + T细胞介导。
J Infect Dis. 2007 Aug 15;196(4):608-16. doi: 10.1086/519742. Epub 2007 Jul 9.
4
Genetically attenuated parasite vaccines induce contact-dependent CD8+ T cell killing of Plasmodium yoelii liver stage-infected hepatocytes.基因减毒寄生虫疫苗可诱导接触依赖性CD8 + T细胞杀伤约氏疟原虫肝期感染的肝细胞。
J Immunol. 2009 Nov 1;183(9):5870-8. doi: 10.4049/jimmunol.0900302. Epub 2009 Oct 7.
5
Protection against malaria by Plasmodium yoelii sporozoite surface protein 2 linear peptide induction of CD4+ T cell- and IFN-gamma-dependent elimination of infected hepatocytes.约氏疟原虫子孢子表面蛋白2线性肽诱导CD4 + T细胞和IFN-γ依赖性清除感染的肝细胞从而预防疟疾
J Immunol. 1996 Nov 1;157(9):4061-7.
6
Primary infection of C57BL/6 mice with Plasmodium yoelii induces a heterogeneous response of NKT cells.用约氏疟原虫对C57BL/6小鼠进行初次感染会诱导自然杀伤T细胞产生异质性反应。
Infect Immun. 2007 May;75(5):2511-22. doi: 10.1128/IAI.01818-06. Epub 2007 Feb 16.
7
Efficient development of plasmodium liver stage-specific memory CD8+ T cells during the course of blood-stage malarial infection.在血液期疟疾感染过程中高效发育疟原虫肝期特异性记忆性CD8 + T细胞。
J Infect Dis. 2007 Dec 15;196(12):1827-35. doi: 10.1086/522965.
8
Association of intermediate T cell receptor cells, mainly their NK1.1(-) subset, with protection from malaria.中间型T细胞受体细胞，主要是其NK1.1(-)亚群与疟疾防护的关联。
Cell Immunol. 2001 Jan 10;207(1):28-35. doi: 10.1006/cimm.2000.1737.
9
Induction of hepatic inflammatory response by Plasmodium berghei sporozoites protects BALB/c mice against challenge with Plasmodium yoelii sporozoites.伯氏疟原虫子孢子诱导的肝脏炎症反应可保护BALB/c小鼠免受约氏疟原虫子孢子攻击。
J Parasitol. 1993 Oct;79(5):763-7.
10
IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model.在约氏疟原虫模型中，IL-12和自然杀伤细胞是由CD8 + T细胞引发的针对疟疾的抗原特异性适应性免疫所必需的。
J Immunol. 1999 Jul 15;163(2):884-92.

引用本文的文献

1
Critical roles of TRAIL in hepatic cell death and hepatic inflammation.肿瘤坏死因子相关凋亡诱导配体（TRAIL）在肝细胞死亡和肝脏炎症中的关键作用。
J Clin Invest. 2004 Jan;113(1):58-64. doi: 10.1172/JCI19255.
2
Comparison of intrahepatic lymphocytes from normal and growth hormone transgenic mice with chronic hepatitis and liver cancer.正常小鼠与生长激素转基因小鼠的肝内淋巴细胞在慢性肝炎和肝癌方面的比较。
Immunology. 1997 Mar;90(3):412-20. doi: 10.1111/j.1365-2567.1997.00412.x.

本文引用的文献

1
Cell adhesion in the immune system.免疫系统中的细胞黏附
Immunol Today. 1993 Mar;14(3):99-102. doi: 10.1016/0167-5699(93)90205-Y.
2
In vivo induction of the nitric oxide pathway in hepatocytes after injection with irradiated malaria sporozoites, malaria blood parasites or adjuvants.注射经辐照的疟原虫子孢子、疟原虫血内寄生虫或佐剂后，肝细胞中一氧化氮途径的体内诱导。
Eur J Immunol. 1993 Apr;23(4):882-7. doi: 10.1002/eji.1830230417.
3
Hepatic stages of malaria: specific and non-specific factors inhibiting the development.疟疾的肝脏期：抑制其发育的特异性和非特异性因素
Parassitologia. 1993 Jul;35 Suppl:59-63.
4
Plasmodium falciparum: phagocytosis by polymorphonuclear leukocytes.恶性疟原虫：被多形核白细胞吞噬。
Science. 1968 Oct 11;162(3850):273-4. doi: 10.1126/science.162.3850.273.
5
The immunological significance of histological changes in the spleen and liver in mouse malaria.小鼠疟疾中脾脏和肝脏组织学变化的免疫学意义。
Clin Exp Immunol. 1973 Mar;13(3):467-78.
6
Killing of Plasmodium falciparum by eosinophil secretory products.嗜酸性粒细胞分泌产物对恶性疟原虫的杀伤作用。
Infect Immun. 1987 Apr;55(4):877-81. doi: 10.1128/iai.55.4.877-881.1987.
7
Cellular response against exoerythrocytic forms of Plasmodium berghei in rats.大鼠针对伯氏疟原虫红细胞外期的细胞反应。
Am J Trop Med Hyg. 1987 Nov;37(3):506-10. doi: 10.4269/ajtmh.1987.37.506.
8
Nitric oxide: a cytotoxic activated macrophage effector molecule.一氧化氮：一种具有细胞毒性的活化巨噬细胞效应分子。
Biochem Biophys Res Commun. 1988 Nov 30;157(1):87-94. doi: 10.1016/s0006-291x(88)80015-9.
9
Early influx of Listeria-reactive T lymphocytes in liver of mice genetically resistant to listeriosis.对李斯特菌病具有遗传抗性的小鼠肝脏中，李斯特菌反应性T淋巴细胞的早期流入。
J Immunol. 1988 Oct 1;141(7):2451-5.
10
Functional role of the alpha-chain of complement receptor type 3 in human eosinophil-dependent antibody-mediated cytotoxicity against schistosomes.补体受体3α链在人嗜酸性粒细胞依赖性抗体介导的抗血吸虫细胞毒性中的功能作用。
J Immunol. 1987 Sep 15;139(6):2059-65.

约氏疟原虫子孢子感染小鼠肝脏淋巴髓样细胞的特征分析。

Characterization of liver lymphomyeloid cells in mice infected with Plasmodium yoelii sporozoites.

作者信息

Faure P, Marussig M, Goossens P, Miltgen F, Mazier D

机构信息

Institut National de la Santé et de la Recherche Médicale, Département de Parasitologie, Groupe Pitié-Salpêtrière, Paris, France.

出版信息

Immunology. 1994 Aug;82(4):645-50.

PMID:7835930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1414910/
Abstract

We have isolated, characterized and quantified the immunocompetent cells present in the extravascular hepatic compartment at various stages after Plasmodium yoelii malaria infection with sporozoites. Cytological analyses revealed a predominantly lymphoid population. In mice with a primary infection, the predominant cells were CD4+, CD8+ and B lymphocytes. In fully protected mice, CD3+ CD4- CD8- and polymorphonuclear cells, particularly eosinophils, were most common. The significance of changes in subpopulations is discussed in relation to antigen presentation and host-protective mechanisms.

摘要

我们已经分离、鉴定并定量了约氏疟原虫子孢子感染后不同阶段肝血管外区室中存在的免疫活性细胞。细胞学分析显示主要是淋巴细胞群体。在初次感染的小鼠中，主要细胞是CD4 +、CD8 +和B淋巴细胞。在完全受保护的小鼠中，CD3 + CD4 - CD8 -细胞和多形核细胞，尤其是嗜酸性粒细胞最为常见。文中讨论了亚群变化与抗原呈递和宿主保护机制相关的意义。