约氏疟原虫子孢子感染小鼠肝脏淋巴髓样细胞的特征分析。
Characterization of liver lymphomyeloid cells in mice infected with Plasmodium yoelii sporozoites.
作者信息
Faure P, Marussig M, Goossens P, Miltgen F, Mazier D
机构信息
Institut National de la Santé et de la Recherche Médicale, Département de Parasitologie, Groupe Pitié-Salpêtrière, Paris, France.
出版信息
Immunology. 1994 Aug;82(4):645-50.
We have isolated, characterized and quantified the immunocompetent cells present in the extravascular hepatic compartment at various stages after Plasmodium yoelii malaria infection with sporozoites. Cytological analyses revealed a predominantly lymphoid population. In mice with a primary infection, the predominant cells were CD4+, CD8+ and B lymphocytes. In fully protected mice, CD3+ CD4- CD8- and polymorphonuclear cells, particularly eosinophils, were most common. The significance of changes in subpopulations is discussed in relation to antigen presentation and host-protective mechanisms.
我们已经分离、鉴定并定量了约氏疟原虫子孢子感染后不同阶段肝血管外区室中存在的免疫活性细胞。细胞学分析显示主要是淋巴细胞群体。在初次感染的小鼠中，主要细胞是CD4 +、CD8 +和B淋巴细胞。在完全受保护的小鼠中，CD3 + CD4 - CD8 -细胞和多形核细胞，尤其是嗜酸性粒细胞最为常见。文中讨论了亚群变化与抗原呈递和宿主保护机制相关的意义。
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