Department of Chemistry, St. Edward's University, Austin, TX, USA.
Department of Biological Sciences, St. Edward's University, Austin, TX, USA.
FEBS Lett. 2021 Jan;595(2):284-293. doi: 10.1002/1873-3468.13998. Epub 2020 Dec 1.
The tuberculous granuloma is a compact aggregate of dormant bacteria encapsulated by host macrophages. It is commonly regarded as a product of the host defense designed to isolate infectious mycobacteria. This work demonstrates that exposure of macrophages to the Mtb heat-shock protein Acr leads to overproduction of the chemokine CXCL16, allowing the mycobacterium to exploit the innate immune response. This induction of chemokine expression is hypothesized to occur through activation of ADAM proteases, providing an immunomodulatory role for Mtb Acr in the formation of the granuloma.
结核肉芽肿是由休眠细菌组成的致密聚集体，被宿主巨噬细胞包裹。它通常被认为是宿主防御的产物，旨在隔离传染性分枝杆菌。这项工作表明，巨噬细胞暴露于 Mtb 热休克蛋白 Acr 会导致趋化因子 CXCL16 的过度产生，使分枝杆菌能够利用先天免疫反应。这种趋化因子表达的诱导被假设是通过激活 ADAM 蛋白酶发生的，为 Mtb Acr 在肉芽肿形成中的免疫调节作用提供了依据。
