Institute of Advanced Synthesis (IAS), Northwestern Polytechnical University (NPU), Xi'an 710072, China.
Chem Commun (Camb). 2020 Dec 7;56(95):15020-15023. doi: 10.1039/d0cc06834a.
A simple and practical method to access N-substituted 2-pyridones via a formal [3+3] annulation of enaminones with acrylates based on RhIII-catalyzed C-H functionalization was developed. Control and deuterated experiments led to a plausible mechanism involving C-H bond cross-coupling and aminolysis cyclization. This strategy provides a short synthesis of structural motifs of N-substituted 2-pyridones.
发展了一种通过基于 RhIII 催化的 C-H 功能化的烯胺酮与丙烯酰胺的[3+3]环加成来制备 N-取代的 2-吡啶酮的简单实用方法。控制和氘代实验提出了一种合理的反应机理，涉及 C-H 键交叉偶联和氨解环化。该策略为 N-取代的 2-吡啶酮的结构基序提供了一种简短的合成方法。
