Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, San Francisco, CA.
J Exp Med. 2021 Feb 1;218(2). doi: 10.1084/jem.20202057.
Although BAFF/BLyS and its receptor, BAFFR, play critical roles in naive B cell survival, the pathways involved in the persistence of memory B cells are largely unknown. In this issue of JEM, two groups, Müller-Winkler et al. (https://doi.org/10.1084/jem.20191393) and Lau et al. (https://doi.org/10.1084/jem.20191167), take complementary approaches to identify an essential role for BAFFR in the survival of memory B cells.
虽然 BAFF/BLyS 和它的受体 BAFFR 在幼稚 B 细胞存活中发挥着关键作用，但记忆 B 细胞持续存在的相关途径在很大程度上仍是未知的。在本期《JEM》中，Müller-Winkler 等人（https://doi.org/10.1084/jem.20191393）和 Lau 等人（https://doi.org/10.1084/jem.20191167）采用互补的方法，鉴定了 BAFFR 在记忆 B 细胞存活中的关键作用。
