MZ B 细胞的自然史。

Natural history of MZ B cells.

机构信息

Scripps Research.

出版信息

J Exp Med. 2021 Apr 5;218(4). doi: 10.1084/jem.20202700.

DOI:10.1084/jem.20202700

PMID:33555296

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7873840/

Abstract

In this issue, Tull et al. (https://doi.org/10.1084/jem.20202001) and Kibler et al. (https://doi.org/10.1084/jem.20201952) track human marginal zone B cell development from early progenitors to the memory compartment, addressing changes in age and autoimmunity, the sequence of development in the gut-associated lymphoid tissue, and clonal sharing among memory cells.

摘要

在本期杂志中，Tull 等人（https://doi.org/10.1084/jem.20202001）和 Kibler 等人（https://doi.org/10.1084/jem.20201952）追踪了人类边缘区 B 细胞从早期祖细胞到记忆区的发育过程，探讨了年龄和自身免疫、肠道相关淋巴组织中发育的顺序以及记忆细胞之间的克隆共享等变化。