Hanson L A, Andersson B, Carlsson B, Dahlgren U, Mellander L, Porras O, Svanborg Edén C, Söderström T
Klin Padiatr. 1985 Jul-Aug;197(4):330-3. doi: 10.1055/s-2008-1033997.
The secretory IgA system is common to all mucosal membranes and is presumably of great importance for their defense. In addition to the secretory IgA antibodies produced in a mucosa in response to a local antigenic stimulus there is a spread of this type of IgA response via committed lymphocytes. They originate from central lymphoid organs in the intestinal (Peyer's patches) and bronchial mucosa (bronchus-associated lymphoid tissue, BALT) which they leave after antigenic exposure. They migrate, or "home", to exocrine glands such as the lacrimal, salivary, mammary and prostatic glands and mucosal membranes of the respiratory, gastrointestinal and genito-urinary tract. Almost half of all lymphocytes may be involved in the production of IgA antibodies. The secretory IgA antibodies are the dominating immunoglobulins in exocrine secretions on mucous membranes. They function primarily by preventing contact between the microbe and the host tissue most commonly attacked in infections, the mucous membrane. The fact that breast-feeding protects the infant against intestinal infections is one good example of the clinical significance of secretory IgA antibodies. This mode of protection can be enhanced by vaccination.
分泌型IgA系统存在于所有黏膜中，对其防御功能可能极为重要。除了黏膜针对局部抗原刺激产生的分泌型IgA抗体外，这种类型的IgA反应还可通过定向淋巴细胞扩散。这些淋巴细胞起源于肠道（派尔集合淋巴结）和支气管黏膜（支气管相关淋巴组织，BALT）中的中枢淋巴器官，在接触抗原后离开这些器官。它们迁移或“归巢”至外分泌腺，如泪腺、唾液腺、乳腺和前列腺，以及呼吸道、胃肠道和泌尿生殖道的黏膜。几乎所有淋巴细胞中有近一半可能参与IgA抗体的产生。分泌型IgA抗体是黏膜外分泌液中的主要免疫球蛋白。它们的主要功能是防止微生物与感染中最常受攻击的宿主组织即黏膜接触。母乳喂养可保护婴儿免受肠道感染，这是分泌型IgA抗体临床意义的一个很好例子。这种保护方式可通过接种疫苗得到增强。
