García-Muro Cristina, Sáenz-Moreno Isabel, Riaño-Méndez Bibiana, Gutiérrez-Delgado Jesús M, Valencia-Ramos Juan, Esteban-Zubero Eduardo
Servicio de Pediatría, Hospital San Pedro, Logroño. España.
Servicio de Anestesiología, Hospital San Pedro, Logroño. España.
Bol Med Hosp Infant Mex. 2020;77(6):337-340. doi: 10.24875/BMHIM.20000047.
Malignant hyperthermia syndrome is a hereditary pharmacogenetic disorder of skeletal muscle characterized by hypermetabolic state related to the exposure of volatile anesthetic gases or depolarizing muscle relaxants. It is an infrequent entity that occurs in genetically predisposed individuals, with a very low incidence in pediatrics (1 in 10,000-15,000 anesthetic procedures).
We report a case of malignant hyperthermia related to exposure to sevoflurane during adenoidectomy surgery in a 6-year-old female. The patient presented with tachycardia, hypercapnia, and hyperthermia, requiring two successive doses of dantrolene sodium administration, with an adequate response to the treatment.
Malignant hyperthermia syndrome is a rare condition in pediatric patients that should be detected in early stages since it is essential to initiate the treatment as soon as possible.
恶性高热综合征是一种遗传性骨骼肌药物遗传学疾病，其特征为与挥发性麻醉气体或去极化肌肉松弛剂暴露相关的高代谢状态。它是一种罕见的疾病，发生于具有遗传易感性的个体，在儿科发病率极低（每10000 - 15000例麻醉手术中有1例）。
我们报告一例6岁女性在腺样体切除术中因接触七氟醚而发生恶性高热的病例。患者出现心动过速、高碳酸血症和高热，需要连续两次给予丹曲林钠，治疗反应良好。
恶性高热综合征在儿科患者中是一种罕见疾病，应尽早发现，因为尽早开始治疗至关重要。
