Department of Psychology, University of Oslo, Oslo, Norway; Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway.
Computational Radiology and Artificial Intelligence (CRAI), Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Neuroimage. 2021 Feb 1;226:117540. doi: 10.1016/j.neuroimage.2020.117540. Epub 2020 Nov 10.
Sleep deprivation influences several critical functions, yet how it affects human brain white matter (WM) is not well understood. The aim of the present work was to investigate the effect of 32 hours of sleep deprivation on WM microstructure compared to changes observed in a normal sleep-wake cycle (SWC). To this end, we utilised diffusion weighted imaging (DWI) including the diffusion tensor model, diffusion kurtosis imaging and the spherical mean technique, a novel biophysical diffusion model. 46 healthy adults (23 sleep deprived vs 23 with normal SWC) underwent DWI across four time points (morning, evening, next day morning and next day afternoon, after a total of 32 hours). Linear mixed models revealed significant group × time interaction effects, indicating that sleep deprivation and normal SWC differentially affect WM microstructure. Voxel-wise comparisons showed that these effects spanned large, bilateral WM regions. These findings provide important insight into how sleep deprivation affects the human brain.
睡眠剥夺会影响多个关键功能，但它如何影响人类大脑白质（WM）尚不清楚。本研究旨在调查与正常睡眠-觉醒周期（SWC）相比，32 小时睡眠剥夺对 WM 微观结构的影响。为此，我们利用弥散加权成像（DWI），包括弥散张量模型、弥散峰度成像和球均值技术，这是一种新的生物物理弥散模型。46 名健康成年人（23 名睡眠剥夺，23 名正常 SWC）在四个时间点（早晨、晚上、第二天早晨和第二天下午，总共 32 小时后）进行 DWI。线性混合模型显示出显著的组×时间交互作用效应，表明睡眠剥夺和正常 SWC 对 WM 微观结构有不同的影响。体素水平比较显示，这些影响跨越了大脑双侧的大片 WM 区域。这些发现为了解睡眠剥夺如何影响人类大脑提供了重要的见解。
