Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan.
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan; National Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan.
J Photochem Photobiol B. 2020 Dec;213:112073. doi: 10.1016/j.jphotobiol.2020.112073. Epub 2020 Oct 29.
Although light emitting diodes (LEDs) are widely used in our daily lives, there is little research regarding LED light's possible effects on biological functions. We used a zebrafish animal model to investigate the long-term effects of white, blue and red LED lights on cognitive learning and memory recall. Our data suggest that these treatments had not only an impact on learning but also surprisingly long-lasting effects, particularly with regard to individuals treated with red light. The qPCR results revealed that the expression levels of trpm4, trpa1b, grin2aa and dlg4 in the skin were increased after monochromatic light treatment. Furthermore, the up-regulation of trpm4 in the brain may correlate to enhanced learning and memory following red-light treatment. Our results identify a light-based stimulation system for enhancing zebrafish learning, which has the potential to provide important insights into the relationship between LED lighting and animal behaviour.
虽然发光二极管（LED）在我们的日常生活中被广泛应用，但对于 LED 光可能对生物功能产生的影响的研究却很少。我们使用斑马鱼动物模型来研究白光、蓝光和红光 LED 灯对认知学习和记忆回忆的长期影响。我们的数据表明，这些处理不仅对学习有影响，而且具有惊人的持久影响，特别是对于接受红光治疗的个体。qPCR 结果显示，单色光处理后皮肤中 trpm4、trpa1b、grin2aa 和 dlg4 的表达水平增加。此外，大脑中 trpm4 的上调可能与红光处理后学习和记忆的增强相关。我们的结果确定了一种基于光的刺激系统，用于增强斑马鱼的学习能力，这有可能为 LED 照明与动物行为之间的关系提供重要的见解。
