Center for Infectious Disease Research, Beijing Frontier Research Center for Biological Structure & Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
Viruses. 2020 Nov 11;12(11):1289. doi: 10.3390/v12111289.
Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are enveloped, positive-sense, single-stranded RNA viruses and causes of epidemic diseases that have resulted in public health emergencies worldwide. Angiotensin-converting enzyme 2 (ACE2) is the receptor that allows the entry of these two viruses into host cells, a key step in the life cycle of the pathogens. The characterization of the interactions of ACE2 with the viral spike glycoproteins and structural studies of the ACE2-binding-induced conformational changes in the viral spike glycoproteins have furthered our understanding of the entry processes of these two viruses, and these studies provide useful information that will facilitate the development of antiviral agents and vaccines to control the diseases.
严重急性呼吸综合征冠状病毒（SARS-CoV）和 SARS-CoV-2 是包膜、正链、单链 RNA 病毒，可引起全球性传染病疫情，已构成公共卫生紧急事件。血管紧张素转换酶 2（ACE2）是这两种病毒进入宿主细胞的受体，是病原体生命周期中的关键步骤。对 ACE2 与病毒刺突糖蛋白相互作用的特性以及 ACE2 结合诱导的病毒刺突糖蛋白构象变化的结构研究，进一步加深了我们对这两种病毒进入过程的理解，这些研究提供了有用的信息，有助于开发抗病毒药物和疫苗来控制这些疾病。
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