通过基于 IMCR 的多米诺/双 CuAAC 点击策略合成含有受限和约束性肽模拟物的聚杂环二聚体。
Synthesis of Polyheterocyclic Dimers Containing Restricted and Constrained Peptidomimetics via IMCR-Based Domino/Double CuAAC Click Strategy.
机构信息
Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, 36050 Guanajuato, Mexico.
出版信息
Molecules. 2020 Nov 11;25(22):5246. doi: 10.3390/molecules25225246.
Abstract
A novel strategy via the triple process (multicomponent reactions (MCR)-domino)/tandem was developed for the synthesis of restricted and constrained bis-1,2,3-triazole-linked pyrrolo[3,4-]pyridine peptidomimetics dimers in overall yields of 20-55%. This strategy allows the construction of six heterocycles in two stages of the reaction.
摘要
开发了一种通过三重过程（多组分反应 (MCR)-级联）/串联的新策略，用于合成受限和约束的双-1,2,3-三唑连接的吡咯并[3,4-]吡啶肽模拟二聚体，总收率为 20-55%。该策略允许在反应的两个阶段构建六个杂环。
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